Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and im... Mehr ...
| Verfasser: |
Forstner, Andreas J
Awasthi, Swapnil
Wolf, Christiane
Maron, Eduard
Erhardt, Angelika
Czamara, Darina
Eriksson, Elias
Lavebratt, Catharina
Allgulander, Christer
Friedrich, Nina
Becker, Jessica
Hecker, Julian
Rambau, Stefanie
Conrad, Rupert
Geiser, Franziska
McMahon, Francis J
Moebus, Susanne
Hess, Timo
Buerfent, Benedikt C
Hoffmann, Per
Herms, Stefan
Heilmann-Heimbach, Stefanie
Kockum, Ingrid
Olsson, Tomas
Alfredsson, Lars
Weber, Heike
Alpers, Georg W
Arolt, Volker
Fehm, Lydia
Fydrich, Thomas
Gerlach, Alexander L
Hamm, Alfons
Kircher, Tilo
Pané-Farré, Christiane A
Pauli, Paul
Rief, Winfried
Ströhle, Andreas
Plag, Jens
Lang, Thomas
Wittchen, Hans-Ulrich
Mattheisen, Manuel
Meier, Sandra
Metspalu, Andres
Domschke, Katharina
Reif, Andreas
Hovatta, Iiris
Lindefors, Nils
Andersson, Evelyn
Schalling, Martin
Mbarek, Hamdi
Milaneschi, Yuri
de Geus, Eco J C
Boomsma, Dorret I
Penninx, Brenda W J H
Thorgeirsson, Thorgeir E
Steinberg, Stacy
Stefansson, Kari
Stefansson, Hreinn
Müller-Myhsok, Bertram
Hansen, Thomas Folkmann
Børglum, Anders D
Werge, Thomas
Mortensen, Preben Bo
Nordentoft, Merete
Hougaard, David M
Hultman, Christina M
Sullivan, Patrick F
Nöthen, Markus M
Woldbye, David P D
Mors, Ole
Binder, Elisabeth B
Rück, Christian
Ripke, Stephan
Deckert, Jürgen
Schumacher, Johannes |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2021 |
| Reihe/Periodikum: |
Forstner , A J , Awasthi , S , Wolf , C , Maron , E , Erhardt , A , Czamara , D , Eriksson , E , Lavebratt , C , Allgulander , C , Friedrich , N , Becker , J , Hecker , J , Rambau , S , Conrad , R , Geiser , F , McMahon , F J , Moebus , S , Hess , T , Buerfent , B C , Hoffmann , P , Herms , S , Heilmann-Heimbach , S , Kockum , I , Olsson , T , Alfredsson , L , Weber , H , Alpers , G W , Arolt , V , Fehm , L , Fydrich , T , Gerlach , A L , Hamm , A , Kircher , T , Pané-Farré , C A , Pauli , P , Rief , W , Ströhle , A , Plag , J , Lang , T , Wittchen , H-U , Mattheisen , M , Meier , S , Metspalu , A , Domschke , K , Reif , A , Hovatta , I , Lindefors , N , Andersson , E , Schalling , M , Mbarek , H , Milaneschi , Y , de Geus , E J C , Boomsma , D I , Penninx , B W J H , Thorgeirsson , T E , Steinberg , S , Stefansson , K , Stefansson , H , Müller-Myhsok , B , Hansen , T F , Børglum , A D , Werge , T , Mortensen , P B , Nordentoft , M , Hougaard , D M , Hultman , C M , Sullivan , P F , Nöthen , M M , Woldbye , D P D , Mors , O , Binder , E B , Rück , C , Ripke , S , Deckert , J & Schumacher , J 2021 , ' Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression ' , Molecular Psychiatry , vol. 26 , no. 8 , pp. 4179-4190 . https://doi.org/10.1038/s41380-019-0590-2 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29211978 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/84a02d59-9cee-4dec-a7ec-4ce0a7730abd |
