This report provides information about the social context of adolescents aged 11 to 18 years old attending Luxembourg public and private schools whose teaching is based on the national curriculum in 2022. In general, age, gender, family affluence, migration background and type of school were associated with the social context indicators in HBSC 2022 Luxembourg Survey. Boys, younger adolescents, those from families with low affluence, first-generation migrants and pupils attending Enseignement Fondamental were more likely to like school a lot and to feel a little or no pressure. Pupils who thought that their teacher(s) considered their school performance below average were more likely to not like school and feel schoolwork pressure. Regarding family and friends, boys more frequently reported to have an (very) easy communication with both their father and their mother and a high family support, while girls perceived higher support from friends. Additionally, adolescents from high affluence families, living with both parents and with no migration background perceived higher support from their family and friends. Furthermore, this report explored non-binary gender identities and compared the perceived social support and mental health of cisgender boys, cisgender girls and non-cisgender individuals in secondary schools. In sum, non-cisgender adolescents reported worse levels of family, friends, teacher and classmate support and lower levels of life satisfaction and well-being compared to their cisgender peers.