Extended (competitive) version of BioRS, implementing alternative aptamer structures and interference.

(A-F) Evolutionary search scheme for the competitive BioRS. (A) An initial arbitrary sequence of a given length with zero fitness. (B-C) The first functional domain (aptamer) is identified by an evolutionary search. It may have one of two alternative structures: cloverleaf or rod (see Fig 4A ). (D) If the cloverleaf structure is found in a certain position, this makes it impossible to find the second functional domain due to steric interactions of two neighboring domains. (E-F) In the case of a rod structure of the already found domain, it is possible to find the second functional domain in on... Mehr ...

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Verfasser: Alexander V. Spirov (11302085)
Ekaterina M. Myasnikova (12008895)
Dokumenttyp: Image
Erscheinungsdatum: 2022
Schlagwörter: Biochemistry / Biotechnology / Evolutionary Biology / Infectious Diseases / Biological Sciences not elsewhere classified / larger building blocks / identifying short schemata / holland &# 8217 / dna -) rna / classical selectionist schemes / biological royal staircase / numerical tests showed / achieve significant savings / functional biological macromolecules / ec extensively study / already found modules / experimental evolutionary search / simple heuristic algorithms / many new algorithms / effective evolutionary search / vitro evolution approaches / biological macromolecules / evolutionary search / new algorithms / heuristic algorithms / significant increase / numerical analysis / evolutionary computation / vitro evolution / vitro </ / search recombine / genetic algorithms / synthetic biology / strong arguments / specific version / seems reasonable / schema theorem / quite suitable / publication arises / originally based / modular organization / key instrument / high fitness / functions ) / essentially accelerating / especially true / effectively applied / ec approaches / directed evolution / computer sciences
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29079232
Datenquelle: BASE; Originalkatalog
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Link(s) : https://doi.org/10.1371/journal.pone.0260497.g005

(A-F) Evolutionary search scheme for the competitive BioRS. (A) An initial arbitrary sequence of a given length with zero fitness. (B-C) The first functional domain (aptamer) is identified by an evolutionary search. It may have one of two alternative structures: cloverleaf or rod (see Fig 4A ). (D) If the cloverleaf structure is found in a certain position, this makes it impossible to find the second functional domain due to steric interactions of two neighboring domains. (E-F) In the case of a rod structure of the already found domain, it is possible to find the second functional domain in one of two alternative structures. This is only case (E) which can evolve further. (G) Schematic of the competitive BioRS illustrating its multimodality (bimodality within each epoch). See text for details.