Extended (competitive) version of BioRS, implementing alternative aptamer structures and interference.

(A-F) Evolutionary search scheme for the competitive BioRS. (A) An initial arbitrary sequence of a given length with zero fitness. (B-C) The first functional domain (aptamer) is identified by an evolutionary search. It may have one of two alternative structures: cloverleaf or rod (see Fig 4A ). (D) If the cloverleaf structure is found in a certain position, this makes it impossible to find the second functional domain due to steric interactions of two neighboring domains. (E-F) In the case of a rod structure of the already found domain, it is possible to find the second functional domain in on... Mehr ...