Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march? ...

Abstract Background Cow’s milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called “allergic march”. We aimed to detect genetic associations of CMA using reported single nucleotide polymorphisms (SNP) in other allergic diseases and genetic mutations within the filaggrin (FLG) gene. Both to investigate possible causes of CMA, which also suggests an “allergic march”. Methods Thirty children from the Dutch EuroPrevall birth cohort study with CMA in infancy... Mehr ...

Verfasser: Henneman, Peter
Petrus, Nicole
Venema, Andrea
Sinderen, Femke
Lip, Karin
Hennekam, Raoul
Mannens, Marcel
Sprikkelman, Aline
Dokumenttyp: Datenquelle
Erscheinungsdatum: 2016
Verlag/Hrsg.: Figshare
Schlagwörter: Medicine / Genetics / FOS: Biological sciences / Molecular Biology / Physiology / Biotechnology / Immunology / FOS: Clinical medicine / 69999 Biological Sciences not elsewhere classified / 19999 Mathematical Sciences not elsewhere classified / FOS: Mathematics / Developmental Biology / Cancer / 110309 Infectious Diseases / FOS: Health sciences
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-28983549
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dx.doi.org/10.6084/m9.figshare.c.3610928

Abstract Background Cow’s milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called “allergic march”. We aimed to detect genetic associations of CMA using reported single nucleotide polymorphisms (SNP) in other allergic diseases and genetic mutations within the filaggrin (FLG) gene. Both to investigate possible causes of CMA, which also suggests an “allergic march”. Methods Thirty children from the Dutch EuroPrevall birth cohort study with CMA in infancy and twenty-three healthy controls were studied. Six candidate SNPs were selected (minor allele frequency 10–50 % combined with a large effect) based on the literature. Thirteen FLG candidate mutations were selected spread over repeats 1, 3, 4, 5, 6, 7, 9 and 10 respectively. Results We found two SNP’s, rs17616434 (P = 0.002) and rs2069772 (P = 0.038), significantly associated with CMA. One is located near the toll like ...