Atezolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance.

Verfasser: Nicolas Lambert
Solène Dauby
Dominique Dive
Bernard Sadzot
Pierre Maquet
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Emerging Infectious Diseases, Vol 28, Iss 1, Pp 253-256 (2022)
Verlag/Hrsg.: Centers for Disease Control and Prevention
Schlagwörter: progressive multifocal leukoencephalopathy / immunotherapy / JC virus / immune reconstitution inflammatory syndrome / Belgium / viruses / Medicine / R / Infectious and parasitic diseases / RC109-216
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28938397
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doi.org/10.3201/eid2801.204809