Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery diseas... Mehr ...
| Verfasser: |
Joshi, Peter K
Pirastu, Nicola
Kentistou, Katherine A
Fischer, Krista
Hofer, Edith
Schraut, Katharina E
Clark, David W
Nutile, Teresa
Barnes, Catriona L K
Timmers, Paul R H J
Shen, Xia
Gandin, Ilaria
McDaid, Aaron F
Hansen, Thomas Folkmann
Gordon, Scott D
Giulianini, Franco
Boutin, Thibaud S
Abdellaoui, Abdel
Zhao, Wei
Medina-Gomez, Carolina
Bartz, Traci M
Trompet, Stella
Lange, Leslie A
Raffield, Laura
van der Spek, Ashley
Galesloot, Tessel E
Proitsi, Petroula
Yanek, Lisa R
Bielak, Lawrence F
Payton, Antony
Murgia, Federico
Concas, Maria Pina
Biino, Ginevra
Tajuddin, Salman M
Seppälä, Ilkka
Amin, Najaf
Boerwinkle, Eric
Børglum, Anders D
Campbell, Archie
Demerath, Ellen W
Demuth, Ilja
Faul, Jessica D
Ford, Ian
Gialluisi, Alessandro
Gögele, Martin
Graff, MariaElisa
Hingorani, Aroon
Hottenga, Jouke-Jan
Hougaard, David M
Hurme, Mikko A
Ikram, M Arfan
Jylhä, Marja
Kuh, Diana
Ligthart, Lannie
Lill, Christina M
Lindenberger, Ulman
Lumley, Thomas
Mägi, Reedik
Marques-Vidal, Pedro
Medland, Sarah E
Milani, Lili
Nagy, Reka
Ollier, William E R
Peyser, Patricia A
Pramstaller, Peter P
Ridker, Paul M
Rivadeneira, Fernando
Ruggiero, Daniela
Saba, Yasaman
Schmidt, Reinhold
Schmidt, Helena
Slagboom, P Eline
Smith, Blair H
Smith, Jennifer A
Sotoodehnia, Nona
Steinhagen-Thiessen, Elisabeth
van Rooij, Frank J A
Verbeek, André L
Vermeulen, Sita H
Vollenweider, Peter
Wang, Yunpeng
Werge, Thomas
Whitfield, John B
Zonderman, Alan B
Lehtimäki, Terho
Evans, Michele K
Pirastu, Mario
Fuchsberger, Christian
Bertram, Lars
Pendleton, Neil
Kardia, Sharon L R
Ciullo, Marina
Becker, Diane M
Wong, Andrew
Psaty, Bruce M
van Duijn, Cornelia M
Wilson, James G
Jukema, J Wouter
Kiemeney, Lambertus
Uitterlinden, André G
Franceschini, Nora
North, Kari E
Weir, David R
Metspalu, Andres
Boomsma, Dorret I
Hayward, Caroline
Chasman, Daniel
Martin, Nicholas G
Sattar, Naveed
Campbell, Harry
Esko, Tōnu
Kutalik, Zoltán
Wilson, James F |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Joshi , P K , Pirastu , N , Kentistou , K A , Fischer , K , Hofer , E , Schraut , K E , Clark , D W , Nutile , T , Barnes , C L K , Timmers , P R H J , Shen , X , Gandin , I , McDaid , A F , Hansen , T F , Gordon , S D , Giulianini , F , Boutin , T S , Abdellaoui , A , Zhao , W , Medina-Gomez , C , Bartz , T M , Trompet , S , Lange , L A , Raffield , L , van der Spek , A , Galesloot , T E , Proitsi , P , Yanek , L R , Bielak , L F , Payton , A , Murgia , F , Concas , M P , Biino , G , Tajuddin , S M , Seppälä , I , Amin , N , Boerwinkle , E , Børglum , A D , Campbell , A , Demerath , E W , Demuth , I , Faul , J D , Ford , I , Gialluisi , A , Gögele , M , Graff , M , Hingorani , A , Hottenga , J-J , Hougaard , D M , Hurme , M A , Ikram , M A , Jylhä , M , Kuh , D , Ligthart , L , Lill , C M , Lindenberger , U , Lumley , T , Mägi , R , Marques-Vidal , P , Medland , S E , Milani , L , Nagy , R , Ollier , W E R , Peyser , P A , Pramstaller , P P , Ridker , P M , Rivadeneira , F , Ruggiero , D , Saba , Y , Schmidt , R , Schmidt , H , Slagboom , P E , Smith , B H , Smith , J A , Sotoodehnia , N , Steinhagen-Thiessen , E , van Rooij , F J A , Verbeek , A L , Vermeulen , S H , Vollenweider , P , Wang , Y , Werge , T , Whitfield , J B , Zonderman , A B , Lehtimäki , T , Evans , M K , Pirastu , M , Fuchsberger , C , Bertram , L , Pendleton , N , Kardia , S L R , Ciullo , M , Becker , D M , Wong , A , Psaty , B M , van Duijn , C M , Wilson , J G , Jukema , J W , Kiemeney , L , Uitterlinden , A G , Franceschini , N , North , K E , Weir , D R , Metspalu , A , Boomsma , D I , Hayward , C , Chasman , D , Martin , N G , Sattar , N , Campbell , H , Esko , T , Kutalik , Z & Wilson , J F 2017 , ' Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity ' , Nature Communications , vol. 8 , no. 1 , 910 , pp. 910 . https://doi.org/10.1038/s41467-017-00934-5 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28800641 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/4b15213a-dfb6-4126-9893-52c169b6e797 |
