Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Verfasser:	Joshi, Peter K Pirastu, Nicola Kentistou, Katherine A Fischer, Krista Hofer, Edith Schraut, Katharina E Clark, David W Nutile, Teresa Barnes, Catriona L K Timmers, Paul R H J Shen, Xia Gandin, Ilaria McDaid, Aaron F Hansen, Thomas Folkmann Gordon, Scott D Giulianini, Franco Boutin, Thibaud S Abdellaoui, Abdel Zhao, Wei Medina-Gomez, Carolina Bartz, Traci M Trompet, Stella Lange, Leslie A Raffield, Laura van der Spek, Ashley Galesloot, Tessel E Proitsi, Petroula Yanek, Lisa R Bielak, Lawrence F Payton, Antony Murgia, Federico Concas, Maria Pina Biino, Ginevra Tajuddin, Salman M Seppälä, Ilkka Amin, Najaf Boerwinkle, Eric Børglum, Anders D Campbell, Archie Demerath, Ellen W Demuth, Ilja Faul, Jessica D Ford, Ian Gialluisi, Alessandro Gögele, Martin Graff, MariaElisa Hingorani, Aroon Hottenga, Jouke-Jan Hougaard, David M Hurme, Mikko A Ikram, M Arfan Jylhä, Marja Kuh, Diana Ligthart, Lannie Lill, Christina M Lindenberger, Ulman Lumley, Thomas Mägi, Reedik Marques-Vidal, Pedro Medland, Sarah E Milani, Lili Nagy, Reka Ollier, William E R Peyser, Patricia A Pramstaller, Peter P Ridker, Paul M Rivadeneira, Fernando Ruggiero, Daniela Saba, Yasaman Schmidt, Reinhold Schmidt, Helena Slagboom, P Eline Smith, Blair H Smith, Jennifer A Sotoodehnia, Nona Steinhagen-Thiessen, Elisabeth van Rooij, Frank J A Verbeek, André L Vermeulen, Sita H Vollenweider, Peter Wang, Yunpeng Werge, Thomas Whitfield, John B Zonderman, Alan B Lehtimäki, Terho Evans, Michele K Pirastu, Mario Fuchsberger, Christian Bertram, Lars Pendleton, Neil Kardia, Sharon L R Ciullo, Marina Becker, Diane M Wong, Andrew Psaty, Bruce M van Duijn, Cornelia M Wilson, James G Jukema, J Wouter Kiemeney, Lambertus Uitterlinden, André G Franceschini, Nora North, Kari E Weir, David R Metspalu, Andres Boomsma, Dorret I Hayward, Caroline Chasman, Daniel Martin, Nicholas G Sattar, Naveed Campbell, Harry Esko, Tōnu Kutalik, Zoltán Wilson, James F
Dokumenttyp:	Artikel
Erscheinungsdatum:	2017
Reihe/Periodikum:	Joshi , P K , Pirastu , N , Kentistou , K A , Fischer , K , Hofer , E , Schraut , K E , Clark , D W , Nutile , T , Barnes , C L K , Timmers , P R H J , Shen , X , Gandin , I , McDaid , A F , Hansen , T F , Gordon , S D , Giulianini , F , Boutin , T S , Abdellaoui , A , Zhao , W , Medina-Gomez , C , Bartz , T M , Trompet , S , Lange , L A , Raffield , L , van der Spek , A , Galesloot , T E , Proitsi , P , Yanek , L R , Bielak , L F , Payton , A , Murgia , F , Concas , M P , Biino , G , Tajuddin , S M , Seppälä , I , Amin , N , Boerwinkle , E , Børglum , A D , Campbell , A , Demerath , E W , Demuth , I , Faul , J D , Ford , I , Gialluisi , A , Gögele , M , Graff , M , Hingorani , A , Hottenga , J-J , Hougaard , D M , Hurme , M A , Ikram , M A , Jylhä , M , Kuh , D , Ligthart , L , Lill , C M , Lindenberger , U , Lumley , T , Mägi , R , Marques-Vidal , P , Medland , S E , Milani , L , Nagy , R , Ollier , W E R , Peyser , P A , Pramstaller , P P , Ridker , P M , Rivadeneira , F , Ruggiero , D , Saba , Y , Schmidt , R , Schmidt , H , Slagboom , P E , Smith , B H , Smith , J A , Sotoodehnia , N , Steinhagen-Thiessen , E , van Rooij , F J A , Verbeek , A L , Vermeulen , S H , Vollenweider , P , Wang , Y , Werge , T , Whitfield , J B , Zonderman , A B , Lehtimäki , T , Evans , M K , Pirastu , M , Fuchsberger , C , Bertram , L , Pendleton , N , Kardia , S L R , Ciullo , M , Becker , D M , Wong , A , Psaty , B M , van Duijn , C M , Wilson , J G , Jukema , J W , Kiemeney , L , Uitterlinden , A G , Franceschini , N , North , K E , Weir , D R , Metspalu , A , Boomsma , D I , Hayward , C , Chasman , D , Martin , N G , Sattar , N , Campbell , H , Esko , T , Kutalik , Z & Wilson , J F 2017 , ' Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity ' , Nature Communications , vol. 8 , no. 1 , 910 , pp. 910 . https://doi.org/10.1038/s41467-017-00934-5
Schlagwörter:	Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-28800641
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/4b15213a-dfb6-4126-9893-52c169b6e797

Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan.Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.