The incidence of Barrett's oesophagus and oesophageal adenocarcinoma in the United Kingdom and the Netherlands is levelling off
Summary Background Barrett's oesophagus ( BO ) is a risk factor for oesophageal adenocarcinoma ( OAC ). Several studies report increasing incidences of BO with substantial variation. Aim To determine age‐ and sex‐stratified incidence rates ( IR ) of BO and OAC . Methods Cohort study using two primary care databases in the United Kingdom ( UK ) and the Netherlands ( NL ) (2000–2012). BO and OAC cases were identified using disease‐specific READ codes ( UK ) and free‐text search with manual validation ( NL ). Age‐ and sex‐specific incidence rates ( IR s) were calculated for both BO and OAC . Resu... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2014 |
Reihe/Periodikum: | Alimentary Pharmacology & Therapeutics ; volume 39, issue 11, page 1321-1330 ; ISSN 0269-2813 1365-2036 |
Verlag/Hrsg.: |
Wiley
|
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27629572 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1111/apt.12759 |
Summary Background Barrett's oesophagus ( BO ) is a risk factor for oesophageal adenocarcinoma ( OAC ). Several studies report increasing incidences of BO with substantial variation. Aim To determine age‐ and sex‐stratified incidence rates ( IR ) of BO and OAC . Methods Cohort study using two primary care databases in the United Kingdom ( UK ) and the Netherlands ( NL ) (2000–2012). BO and OAC cases were identified using disease‐specific READ codes ( UK ) and free‐text search with manual validation ( NL ). Age‐ and sex‐specific incidence rates ( IR s) were calculated for both BO and OAC . Results From the study population of 6 885 420 subjects in the UK , we identified 12 312 incident BO and 40 (0.3%) subsequent incident OAC cases. There were 1383 incident BO , and subsequent 5 (0.4%) incident OAC cases among the 1 487 191 subjects in the NL . The IR of BO increased linearly with age: 15.6/100 000 PY s ( UK ) and 23.7/100 000 PY s ( NL ) for patients aged 40–44 years, increasing to 85.6/100 000 PY s ( UK ) and 87.0/100 000 PY s ( NL ) for 70–74 years. In both the UK and the NL , IR of BO was 2–4 times higher in males than females across all age groups. With respect to calendar time, the IR of BO increased by 35% ( UK ) and 41% ( NL ) from 2000 to 2003, after which IR s remained stable until 2012. Conclusions The incidence rates of BO in the UK and the NL increased until 2003, but levelled off thereafter. Around 0.3% of patients with BO developed OAC at least 1 year after BO diagnosis. These findings may help tailor endoscopic surveillance strategies among patients with BO .