Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Context Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective To investigate the associations between VDR gene variants and mortality among older people. Design The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (≥65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI , three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the Bs... Mehr ...

Verfasser: de Jongh, Renate T
Lips, Paul
Rijs, Kelly J
van Schoor, Natasja M
Kramer, Mark H H
Vandenbroucke, Jan P
Dekkers, Olaf M
Dokumenttyp: Artikel
Erscheinungsdatum: 2011
Reihe/Periodikum: European Journal of Endocrinology ; volume 164, issue 1, page 75-82 ; ISSN 0804-4643 1479-683X
Verlag/Hrsg.: Oxford University Press (OUP)
Schlagwörter: Endocrinology / General Medicine / Diabetes and Metabolism
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-26665309
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://dx.doi.org/10.1530/eje-10-0688

Context Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective To investigate the associations between VDR gene variants and mortality among older people. Design The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (≥65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI , three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI , ApaI , and TaqI polymorphisms. Results During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2 – GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01–1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2 – GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copies=reference, HR, 95% CI: 1 copy 2.01, 0.99–4.07 and 2 copies 1.81, 0.87–4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2 – GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83–1.41). Conclusions The Cdx2 – GATA haplotype 1 allele was related to increased mortality risk, which may be partly explained by osteoporotic fractures. As the biological mechanism is uncertain and this study size is limited, our results should be interpreted as hypothesis generating.