The role of aberrant expression of T cell miRNAs affected by TNF-Alpha in the immunopathogenesis of rheumatoid arthritis

RA patients of male sex had a significant 0.27-fold decrease (p?=?0.019; 95% CI 0.09-0.78) and the use of biologic agents had a significant 4.48-fold increase (p?=?0.001; 95% CI 2.02-9.90) in miR-204 expression levels. [...]RA patients with each 1 mg/dL increment of CRP levels had a significant 0.65-fold decrease (p?=?0.025; 95% CI 0.45-0.94) and the use of biologic agents had a significant 2.44-fold increase (p?=?0.032; 95% CI 1.08-5.48) in miR-214 expression levels. Increased phosphorylation of ERK and JNK has been documented in T cells from patients with RA in previous research [17, 18]. [.... Mehr ...