In economic geography, geographical proximity has been identified as a key driver of M & A activity. In this context, little attention has yet been drawn to the effect of industrial relatedness, which refers to the similarity and complementarity of business activities. We examine 1,855 domestic M & A deals announced between 2002 and 2008 in the N etherlands, and we assess the extent to which geographical proximity and industrial relatedness affect M & A partnering. Our study shows that geographical proximity drives domestic M & A deals, even at very detailed spatial scales like the municipality level. We also found evidence that companies that share the same or complementary industries are more likely to engage in an M & A deal. Logistic regressions show that the effect of industrial relatedness is stronger than the effect of geographical proximity and that the effect of geographical proximity is stronger in unrelated than related target selection.