Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1 production
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule that plays a critical role in autoimmune diseases. However, the function of IL-22 in the pathogenesis of RA remains controversial. In this study, we investigated the role of IL-22 in the early phase of antigen-induced arthritis (AIA) in mice. AIA was induced in C57BL/6, IL-22 .sup.?/?.sup. The IL-22 mRNA expression and protein levels in synovial tissue were increased during the onset of A... Mehr ...
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Dokumenttyp: | Artikel |
Reihe/Periodikum: | Arthritis research & therapy |
Verlag/Hrsg.: |
London,
BioMed Central
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Sprache: | Englisch |
ISSN: | 1478-6354 |
Weitere Identifikatoren: | doi: 10.1186/s13075-015-0759-2 |
Permalink: | https://search.fid-benelux.de/Record/olc-benelux-1961019817 |
URL: | NULL NULL |
Datenquelle: | Online Contents Benelux; Originalkatalog |
Powered By: | Verbundzentrale des GBV (VZG) |
Link(s) : | http://dx.doi.org/10.1186/s13075-015-0759-2
http://dx.doi.org/10.1186/s13075-015-0759-2 |