Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways

The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell activation and is also an important therapeutic target for autoimmune diseases. Little is known about the regulation and functional properties of the soluble PD-1 (sPD-1) variant. The aim of this study was to examine the role of sPD-1 in the regulation of human and murine rheumatoid arthritis (RA). Expression of cytokines and sPD-1 in sera, synovial fluid, and peripheral blood (PB) mononuclear cells of patients with RA were analyzed by enzyme-linked immunosorbent assay and quantitative polymerase chain reaction. PD-1... Mehr ...

Verfasser: Liu, Cuiping
Dokumenttyp: Artikel
Reihe/Periodikum: Arthritis research & therapy
Verlag/Hrsg.: London, BioMed Central
Sprache: Englisch
ISSN: 1478-6354
Permalink: https://search.fid-benelux.de/Record/olc-benelux-1961019035
Datenquelle: Online Contents Benelux; Originalkatalog
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