Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways
The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell activation and is also an important therapeutic target for autoimmune diseases. Little is known about the regulation and functional properties of the soluble PD-1 (sPD-1) variant. The aim of this study was to examine the role of sPD-1 in the regulation of human and murine rheumatoid arthritis (RA). Expression of cytokines and sPD-1 in sera, synovial fluid, and peripheral blood (PB) mononuclear cells of patients with RA were analyzed by enzyme-linked immunosorbent assay and quantitative polymerase chain reaction. PD-1... Mehr ...
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| Dokumenttyp: | Artikel |
| Reihe/Periodikum: | Arthritis research & therapy |
| Verlag/Hrsg.: |
London,
BioMed Central
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| Sprache: | Englisch |
| ISSN: | 1478-6354 |
| Permalink: | https://search.fid-benelux.de/Record/olc-benelux-1961019035 |
| Datenquelle: | Online Contents Benelux; Originalkatalog |
| Powered By: | Verbundzentrale des GBV (VZG) |
