Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling
Interleukin-1β (IL-1β) and nerve growth factor (NGF) are key regulators in the pathogenesis of inflammatory arthritis; specifically, IL-1β is involved in tissue degeneration and NGF is involved in joint pain. However, the cellular and molecular interactions between IL-1β and NGF in articular cartilage are not known. Cartilage stem/progenitor cells (CSPCs) have recently been identified in osteoarthritic (OA) cartilage on the basis of their migratory properties. Here we hypothesize that IL-1β/NGF signaling is involved in OA cartilage degeneration by targeting CSPCs. NGF and NGF receptor (NGFR: T... Mehr ...
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| Dokumenttyp: | Artikel |
| Reihe/Periodikum: | Arthritis research & therapy |
| Verlag/Hrsg.: |
London,
BioMed Central
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| Sprache: | Englisch |
| ISSN: | 1478-6354 |
| Permalink: | https://search.fid-benelux.de/Record/olc-benelux-1961018217 |
| Datenquelle: | Online Contents Benelux; Originalkatalog |
| Powered By: | Verbundzentrale des GBV (VZG) |
