Suppressed diversity of survivin splicing in active rheumatoid arthritis
Alternative splicing distinguishes normal and pathologic cells. High levels of oncoprotein survivin recognise patients with severe rheumatoid arthritis (RA). Here, we assess clinical relevance of alternative splicing of survivin in leukocytes of peripheral blood (PBMC) and bone marrow (BM) in RA patients. Transcription of survivin wild-type (survivin-WT), survivin-2B and survivin-ΔEx3 was measured in 67 randomly selected RA patients and in 23 patients before and after B cell depletion with rituximab. Analysis was done in relation to disease activity, anti-rheumatic treatment and serum levels o... Mehr ...
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|---|---|
| Dokumenttyp: | Artikel |
| Reihe/Periodikum: | Arthritis research & therapy |
| Verlag/Hrsg.: |
London,
BioMed Central
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| Sprache: | Englisch |
| ISSN: | 1478-6354 |
| Permalink: | https://search.fid-benelux.de/Record/olc-benelux-1961016249 |
| Datenquelle: | Online Contents Benelux; Originalkatalog |
| Powered By: | Verbundzentrale des GBV (VZG) |
