BackgroundThe primary rescue medication to treat acute asthma exacerbation is the short-acting β₂-adrenergic receptor agonist; however, there is variation in how well a patient responds to treatment. Although these differences might be due to environmental factors, there is mounting evidence for a genetic contribution to variability in bronchodilator response (BDR).ObjectiveTo identify genetic variation associated with bronchodilator drug response in Latino children with asthma.MethodsWe performed a genome-wide association study (GWAS) for BDR in 1782 Latino children with asthma using standard... Mehr ...
| Verfasser: |
Drake, Katherine A
Torgerson, Dara G
Gignoux, Christopher R
Galanter, Joshua M
Roth, Lindsey A
Huntsman, Scott
Eng, Celeste
Oh, Sam S
Yee, Sook Wah
Lin, Lawrence
Bustamante, Carlos D
Moreno-Estrada, Andrés
Sandoval, Karla
Davis, Adam
Borrell, Luisa N
Farber, Harold J
Kumar, Rajesh
Avila, Pedro C
Brigino-Buenaventura, Emerita
Chapela, Rocio
Ford, Jean G
LeNoir, Michael A
Lurmann, Fred
Meade, Kelley
Serebrisky, Denise
Thyne, Shannon
Rodríguez-Cintrón, William
Sen, Saunak
Rodríguez-Santana, José R
Hernandez, Ryan D
Giacomini, Kathleen M
Burchard, Esteban G |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2014 |
| Reihe/Periodikum: |
Journal of Allergy and Clinical Immunology, vol 133, iss 2 |
| Verlag/Hrsg.: |
eScholarship
University of California
|
| Schlagwörter: |
Pharmacology and Pharmaceutical Sciences
/ Biomedical and Clinical Sciences
/ Clinical Research
/ Patient Safety
/ Asthma
/ Genetics
/ Lung
/ Human Genome
/ Aetiology
/ 2.1 Biological and endogenous factors
/ Respiratory
/ Adolescent
/ Adult
/ Albuterol
/ Bronchodilator Agents
/ Child
/ Forced Expiratory Volume
/ Genome-Wide Association Study
/ Genotype
/ Hispanic or Latino
/ Humans
/ Polymorphism
/ Single Nucleotide
/ Young Adult
/ Bronchodilator response
/ admixture mapping
/ Latinos
/ rare variants
/ BDR
/ GALA I
/ GALA II
/ GWAS
/ Genes-Environments & Admixture in Latino Americans
/ Genetics of Asthma in Latino Americans
/ IGF
/ Insulin-like growth factor
/ LD
/ Linkage disequilibrium
/ MAF
/ Minor allele frequency
/ QC
/ Quality control
/ SABA
/ SLC
/ SNP
/ Short-acting β(2)-adrenergic receptor agonist
/ Single nucleotide polymorphism |
| Sprache: |
unknown |
| Permalink: |
https://search.fid-benelux.de/Record/base-30504884 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://escholarship.org/uc/item/0573g4jn |
