Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.
| Verfasser: |
Roos, L.
van Dongen, J.
Bell, C.G.
Burri, A.
Deloukas, P.
Boomsma, D.I.
Spector, T.D.
Bell, J.T. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
Roos , L , van Dongen , J , Bell , C G , Burri , A , Deloukas , P , Boomsma , D I , Spector , T D & Bell , J T 2016 , ' Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs ' , Clinical epigenetics , vol. 8 , no. 7 , pp. 1-16 . https://doi.org/10.1186/s13148-016-0172-y |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-30454625 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/3cc64244-c5b5-4960-9186-b6c23a44c524 |
