Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels.We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ~120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels... Mehr ...
| Verfasser: |
de Vries, P.S.
Chasman, D.I.
Sabater-Lleal, M.
Chen, M.H.
Huffman, J.E.
Steri, M.
Tang, W.
Teumer, A.
Marioni, R.E.
Grossmann, V.
Hottenga, J.J.
Willemsen, G.
de Geus, E.J.C.
Boomsma, D.I.
Cucca, F.
Tracy, R.
Watkins, H.
Reiner, A.P.
Folsom, A.R.
Ridker, P.M.
O'Donnell, C.J.
Smith, N.L.
Strachan, D.P.
Dehghan, A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
de Vries , P S , Chasman , D I , Sabater-Lleal , M , Chen , M H , Huffman , J E , Steri , M , Tang , W , Teumer , A , Marioni , R E , Grossmann , V , Hottenga , J J , Willemsen , G , de Geus , E J C , Boomsma , D I , Cucca , F , Tracy , R , Watkins , H , Reiner , A P , Folsom , A R , Ridker , P M , O'Donnell , C J , Smith , N L , Strachan , D P & Dehghan , A 2016 , ' A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration ' , Human Molecular Genetics , vol. 25 , no. 2 , pp. 358-370 . https://doi.org/10.1093/hmg/ddv454 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29631582 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/c5154c10-6a63-4940-9807-d5960ef6e40d |
