Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at as... Mehr ...

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Verfasser: Demenais, Florence
Margaritte-Jeannin, Patricia
Barnes, Kathleen C
Cookson, William O C
Altmüller, Janine
Ang, Wei
Barr, R Graham
Beaty, Terri H
Becker, Allan B
Beilby, John
Bisgaard, Hans
Bjornsdottir, Unnur Steina
Bleecker, Eugene
Bønnelykke, Klaus
Boomsma, Dorret I
Bouzigon, Emmanuelle
Brightling, Christopher E
Brossard, Myriam
Brusselle, Guy G
Burchard, Esteban
Burkart, Kristin M
Bush, Andrew
Chan-Yeung, Moira
Chung, Kian Fan
Couto Alves, Alexessander
Curtin, John A
Custovic, Adnan
Daley, Denise
de Jongste, Johan C
Del-Rio-Navarro, Blanca E
Donohue, Kathleen M
Duijts, Liesbeth
Eng, Celeste
Eriksson, Johan G
Farrall, Martin
Fedorova, Yuliya
Feenstra, Bjarke
Ferreira, Manuel A
Freidin, Maxim B
Gajdos, Zofia
Gauderman, Jim
Gehring, Ulrike
Geller, Frank
Genuneit, Jon
Gharib, Sina A
Gilliland, Frank
Heckbert, Susan R
Hottenga, Jouke
Mbarek, Hamdi
Willemsen, Gonneke
Dokumenttyp: Artikel
Erscheinungsdatum: 2018
Reihe/Periodikum: Demenais , F , Margaritte-Jeannin , P , Barnes , K C , Cookson , W O C , Altmüller , J , Ang , W , Barr , R G , Beaty , T H , Becker , A B , Beilby , J , Bisgaard , H , Bjornsdottir , U S , Bleecker , E , Bønnelykke , K , Boomsma , D I , Bouzigon , E , Brightling , C E , Brossard , M , Brusselle , G G , Burchard , E , Burkart , K M , Bush , A , Chan-Yeung , M , Chung , K F , Couto Alves , A , Curtin , J A , Custovic , A , Daley , D , de Jongste , J C , Del-Rio-Navarro , B E , Donohue , K M , Duijts , L , Eng , C , Eriksson , J G , Farrall , M , Fedorova , Y , Feenstra , B , Ferreira , M A , Freidin , M B , Gajdos , Z , Gauderman , J , Gehring , U , Geller , F , Genuneit , J , Gharib , S A , Gilliland , F , Heckbert , S R , Hottenga , J , Mbarek , H , Willemsen , G & Australian Asthma Genetics Consortium (AAGC) collaborators 2018 , ' Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks ' , Nature Genetics , vol. 50 , no. 1 , pp. 42-53 . https://doi.org/10.1038/s41588-017-0014-7
Schlagwörter: Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29627748
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/088c80c2-acad-46c7-9421-849ead188d9d

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.