The impact of HPV vaccination on HPV and cervical cancer in the Netherlands
Human papillomavirus (HPV) is a highly prevalent sexually transmitted virus, of which 150 types have been completely sequenced. Currently, about 14 HPV-types are considered ‘high risk’ for their potential to cause cervical cancer, the fourth most common cancer among women worldwide. In particular HPV-16 and HPV-18 are predominantly present in precancerous lesions and invasive cervical cancer. Luckily, vaccines have been developed to protect against these HPV-types. This thesis includes modeling studies in which we explore the role of naturally acquired immunity after clearing an HPV-16 and HPV... Mehr ...
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| Dokumenttyp: | doctoralThesis |
| Erscheinungsdatum: | 2017 |
| Schlagwörter: | Human papillomavirus / HPV / cervical cancer / vaccination / screening / mathematical modeling / microsimulation |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29616843 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://repub.eur.nl/pub/98975 |
Human papillomavirus (HPV) is a highly prevalent sexually transmitted virus, of which 150 types have been completely sequenced. Currently, about 14 HPV-types are considered ‘high risk’ for their potential to cause cervical cancer, the fourth most common cancer among women worldwide. In particular HPV-16 and HPV-18 are predominantly present in precancerous lesions and invasive cervical cancer. Luckily, vaccines have been developed to protect against these HPV-types. This thesis includes modeling studies in which we explore the role of naturally acquired immunity after clearing an HPV-16 and HPV-18 infection in the spread of HPV, as well as the impact of HPV vaccination on HPV and cervical cancer in the Netherlands.