Microvascular Phenotyping in the Maastricht Study: Design and Main Findings, 2010-2018

Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia, and depression. Recent technical advances have enabled noninvasive measurement and quantification of microvascular changes in humans. In this paper, we describe the protocols of the microvascular measurements applied in the Maastricht Study, an ongoing prospective, population-based cohort study of persons aged 40–75 years being carried out in the southern part of the Netherlands (baseline data assessment, November 2010–January... Mehr ...

Verfasser: Li, Wenjie
Schram, Miranda T.
Soerensen, Ben M.
van Agtmaal, Marnix J. M.
Berendschot, Tos T. J. M.
Webers, Carroll A. B.
Jansen, Jacobus F.A.
Backes, Walter H.
Gronenschild, Ed H. B. M.
Schalkwijk, Casper G.
Stehouwer, Coen D. A.
Houben, Alfons J. H. M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Li , W , Schram , M T , Soerensen , B M , van Agtmaal , M J M , Berendschot , T T J M , Webers , C A B , Jansen , J F A , Backes , W H , Gronenschild , E H B M , Schalkwijk , C G , Stehouwer , C D A & Houben , A J H M 2020 , ' Microvascular Phenotyping in the Maastricht Study: Design and Main Findings, 2010-2018 ' , American Journal of Epidemiology , vol. 189 , no. 9 , pp. 873-884 . https://doi.org/10.1093/aje/kwaa023
Schlagwörter: cardiovascular disease / microvascular dysfunction / pathophysiology / population-based studies / type 2 diabetes / Prospective Studies / Biomarkers/analysis / Humans / Middle Aged / Male / Cardiovascular Diseases/blood / Microcirculation / Adult / Female / Netherlands/epidemiology / Diabetes Mellitus / Type 2/blood / Disease Progression / Diagnostic Imaging / Microvessels/diagnostic imaging / Phenotype / Aged / Research Design / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29612462
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.tue.nl/en/publications/9afa822a-d747-4957-8ff3-50415dc33a8c

Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia, and depression. Recent technical advances have enabled noninvasive measurement and quantification of microvascular changes in humans. In this paper, we describe the protocols of the microvascular measurements applied in the Maastricht Study, an ongoing prospective, population-based cohort study of persons aged 40–75 years being carried out in the southern part of the Netherlands (baseline data assessment, November 2010–January 2020). The study includes a variety of noninvasive measurements in skin, retina, brain, and sublingual tissue, as well as plasma and urine biomarker assessments. Following this, we summarize our main findings involving these microvascular measurements through the end of 2018. Finally, we provide a brief perspective on future microvascular investigations within the framework of the Maastricht Study.