Urbanization leads to changes in the surface cover that alter the hydrological cycle of cities, particularly by increasing the impervious area and, thereby, reducing the interception, storage and infiltration capacity of rainwater. Nature-based solutions (NBS) can contribute to flood risk mitigation in urbanized areas by restoring hydrological functions. However, the effects of NBS on flood risk mitigation are complex and can differ substantially with the type of the NBS. Therefore, the effectiveness of NBS at the urban catchment scale is still subject to much debate, especially at the scale of urban catchments. In this study, the effects of different NBS on urban flood mitigation were evaluated for the city of Eindhoven in The Netherlands, as it has a history of urban flood events. To this end, various NBS scenarios were defined by municipal stakeholders and their impacts modelled with the numerical model Infoworks ICM. This was done for design storms with short, medium and long return periods (5, 10 and 100 years). Overall, the simulated NBS were effective in flood risk mitigation, reducing the flooded area as well as flood depth. The effectiveness of the individual NBS scenarios, however, depended strongly on the location and extension of the NBS, as well as on storm intensity. The effectiveness tended to increase with the increase in NBS surface area, while it tended to decrease with increasing storm intensity and, hence, return period. The NBS solution increasing street water storage was revealed to be more effective than those involving green car parks and green roofs. This study showed that numerical flooding models can be useful tools to assess the effects of NBS to reduce flood extent, water depth and/or velocity, providing insights that can support city planners to design and compare alternative strategies and plans for urban flood risk mitigation.