APC mutations in sporadic colorectal carcinomas from the Netherlands cohort study

The adenomatous polyposis coli ( APC ) gene is considered to be a gatekeeper in colorectal tumourigenesis. Inactivating mutations in APC have been reported in 34-70% of sporadic colorectal cancer patients, the majority of which occur in the mutation cluster region (MCR). In this study, tumour tissue from 665 incident colorectal cancer patients, who originate from 120,852 men and women (55-69 years of age at baseline) participating in the Netherlands Cohort Study, was evaluated for the occurrence and type of APC mutations with regard to age at diagnosis, gender, family history of colorectal can... Mehr ...