Mycobacterium canettii, the Smooth Variant of M. tuberculosis, Isolated from a Swiss Patient Exposed in Africa

An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this pat... Mehr ...

Verfasser: Gaby E. Pfyffer
Raymond Auckenthaler
Jan D. A. van Embden
Dick van Soolingen
Dokumenttyp: Artikel
Erscheinungsdatum: 1998
Reihe/Periodikum: Emerging Infectious Diseases, Vol 4, Iss 4, Pp 631-634 (1998)
Verlag/Hrsg.: Centers for Disease Control and Prevention
Schlagwörter: Kenya / Switzerland / the Netherlands / Medicine / R / Infectious and parasitic diseases / RC109-216
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29588239
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doi.org/10.3201/eid0404.980414

An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this patient probably contracted the infection in Africa, which raises questions about the geographic distribution of M. canettii.