Cities are increasingly recognized as potential motors of sustainability transitions. Infrastructure interdependencies have significant implications for both enabling or restricting urban sustainability transitions but their implications remain understudied. We elaborate the role of interdependent infrastructure systems from a socio-technical perspective and explore the recent examples of how socio-technical interdependencies in infrastructure systems can influence urban sustainability efforts. We build on infrastructure interdependency examples in the Netherlands due to its high urbanization rates, dense urban areas, and respective developments in the infrastructure transitions. We distinguish seven socio-technical infrastructure interdependency types that can influence urban sustainability transitions: functional, evolutionary, spatial, life-cycle, policy/procedural, market, and culture/norm interdependencies. We identify and discuss contrasting multi-mode relationships of each interdependency example. Our ...