peer reviewed ; This study aims to improve our understanding of the changes in the couple and family lives of stroke survivors’ caregivers and to analyse the relationships between the Caregivers’ Life Satisfaction (CLS) and the social and emotional repercussions of the caregiving role, two years after this event. Life satisfaction, optimism about the future, happiness and other subjective well-being aspects have attracted the European policymakers, leading to the Eurofund to introduce a “life satisfaction” dimension in the European Quality of Life Surveys (EQLS). The general subjective appraisal of one’s life is now an indicator next to objective measures of economic performance, such as GDP. How is life satisfaction for the main informal caregivers of stroke-survivors, at the Grand-duchy of Luxembourg (one of the smallest UE country, 502 500 hab. (01/2010), 2600 km2). Individual and family upheavals stroke-related have a major effect on the survivor’s life, and on the close relatives and friends’ ones. «The self-assertion on the harmony of the stroke survivor-caregiver pairs» is the strategy to approach the issue. The implications of these changes are determined by the partners’ trajectory. The CLS is disrupted by stroke, but a lack of information remains on caregivers’ needs, mostly on the repercussions on the couple and family relationships and projects. Over twelve months, 62 pairs (among them 51 couples) of stroke survivors (64.4 mean age; majors impairments: sensory 53.2% and memory 38.7%) and their main informal caregivers (62 mean age, 61.7% women) consented to participate at a National Survey. Research assistants interviewed them at home, with a face-to-face questionnaire. Caregivers evaluated, on a four-point scale, a list of repercussions; these assertions were built up from a qualitative exploratory study. The LS ten-point scaled was dichotomised in “low (<=7 of 10)” and “high (>7 of 10) life satisfaction” (LLS vs HLS)”. Our research protocol was approved by the National Committee of Research ...