Dutch genome diagnostic laboratories accelerated and improved variant interpretation and increased accuracy by sharing data

Each year diagnostic laboratories in the Netherlands profile thousands of individuals for heritable disease using next-generation sequencing (NGS). This requires pathogenicity classification of millions of DNA variants on the standard 5-tier scale. To reduce time spent on data interpretation and increase data quality and reliability, the nine Dutch labs decided to publicly share their classifications. Variant classifications of nearly 100,000 unique variants were catalogued and compared in a centralized MOLGENIS database. Variants classified by more than one center were labeled as “consensus”... Mehr ...

Verfasser: Fokkema, Ivo F.A.C.
van der Velde, Kasper J.
Slofstra, Mariska K.
Ruivenkamp, Claudia A.L.
Vogel, Maartje J.
Pfundt, Rolph
Blok, Marinus J.
Lekanne Deprez, Ronald H.
Waisfisz, Quinten
Abbott, Kristin M.
Sinke, Richard J.
Rahman, Rubayte
Nijman, Isaäc J.
de Koning, Bart
Thijs, Gert
Wieskamp, Nienke
Moritz, Ruben J.G.
Charbon, Bart
Saris, Jasper J.
den Dunnen, Johan T.
Laros, Jeroen F.J.
Swertz, Morris A.
van Gijn, Marielle E.
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Schlagwörter: data sharing / database / diagnostics / NGS / whole-exome sequencing / Genetics / Genetics(clinical)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29455416
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dspace.library.uu.nl/handle/1874/394322

Each year diagnostic laboratories in the Netherlands profile thousands of individuals for heritable disease using next-generation sequencing (NGS). This requires pathogenicity classification of millions of DNA variants on the standard 5-tier scale. To reduce time spent on data interpretation and increase data quality and reliability, the nine Dutch labs decided to publicly share their classifications. Variant classifications of nearly 100,000 unique variants were catalogued and compared in a centralized MOLGENIS database. Variants classified by more than one center were labeled as “consensus” when classifications agreed, and shared internationally with LOVD and ClinVar. When classifications opposed (LB/B vs. LP/P), they were labeled “conflicting”, while other nonconsensus observations were labeled “no consensus”. We assessed our classifications using the InterVar software to compare to ACMG 2015 guidelines, showing 99.7% overall consistency with only 0.3% discrepancies. Differences in classifications between Dutch labs or between Dutch labs and ACMG were mainly present in genes with low penetrance or for late onset disorders and highlight limitations of the current 5-tier classification system. The data sharing boosted the quality of DNA diagnostics in Dutch labs, an initiative we hope will be followed internationally. Recently, a positive match with a case from outside our consortium resulted in a more definite disease diagnosis.