CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles
Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2017 |
| Reihe/Periodikum: | Koopmans , A B , Vinkers , D J , Gelan , P J A , Hoek , H W & van Harten , P N 2017 , ' CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles ' , Pharmacogenomics , vol. 18 , no. 10 , pp. 1003-1012 . https://doi.org/10.2217/pgs-2017-0011 |
| Schlagwörter: | Caribbean / CYP2C19 / CYP2D6 / ethnicity / prevalence / psychiatry / DEBRISOQUINE 4-HYDROXYLASE CYP2D6 / GENETIC POLYMORPHISMS / TARDIVE-DYSKINESIA / HEALTHY-VOLUNTEERS / COST-EFFECTIVENESS / ALLELE FREQUENCY / SCHIZOPHRENIA / CYTOCHROME-P450 / PHARMACOGENETICS / IMPLEMENTATION |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29437552 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/db74ceb2-8965-4344-98e5-037789d3f4e0 |
Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.