Background: Adjuvant anti-PD-1 therapy improves relapse free survival in stage III melanoma, but also leads to immune-related adverse events (irAEs). Older patients are of particular interest due to comorbidities and frailty, which may impact their ability to tolerate irAEs and benefit from anti-PD-1 therapy. This study aimed to explore associations between clinical parameters and the occurrence of grade = 3 irAEs and recurrence-free survival (RFS) in older patients with radically resected stage III/IV cutaneous melanoma treated with adjuvant anti-PD-1 therapy. Methods: Patients aged = 65 with... Mehr ...
| Verfasser: |
Özkan, A.
Kapiteijn, E.
van den Bos, F.
Aarts, M. J.B.
van den Berkmortel, F. W.P.J.
Blank, C. U.
Bloem, M.
Blokx, W. A.M.
Boers-Sonderen, M. J.
Bonenkamp, J. J.
van den Eertwegh, A. J.M.
de Groot, J. W.B.
Haanen, J. B.
Holtslag, C. E.
Hospers, G. A.P.
Piersma, D.
van Rijn, R. S.
Stevense-den Boer, A. M.
Suijkerbuijk, K. P.M.
van der Veldt, A. A.M.
Vreugdenhil, G.
Wouters, M. W.J.M.
Portielje, J. E.A.
de Glas, N. A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2024 |
| Reihe/Periodikum: |
Özkan , A , Kapiteijn , E , van den Bos , F , Aarts , M J B , van den Berkmortel , F W P J , Blank , C U , Bloem , M , Blokx , W A M , Boers-Sonderen , M J , Bonenkamp , J J , van den Eertwegh , A J M , de Groot , J W B , Haanen , J B , Holtslag , C E , Hospers , G A P , Piersma , D , van Rijn , R S , Stevense-den Boer , A M , Suijkerbuijk , K P M , van der Veldt , A A M , Vreugdenhil , G , Wouters , M W J M , Portielje , J E A & de Glas , N A 2024 , ' Adjuvant immunotherapy in older patients with stage III and resected stage IV melanoma : Toxicity and recurrence-free survival outcomes from the Dutch melanoma treatment registry ' , European Journal of Cancer , vol. 212 , 115056 . https://doi.org/10.1016/j.ejca.2024.115056 |
| Schlagwörter: |
Immune checkpoint inhibitors
/ Immune-related adverse events
/ Melanoma
/ Oncology
/ Recurrence-free survival |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29437407 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/b83380c0-7bea-4eda-9141-859cccddf6eb |
