Numerical optimization is gradually finding its way into drinking water practice. For successful introduction of optimization into the sector, it is important that researchers and utility experts work together on the problem formulation with the water utility experts. Water utilities heed the solutions provided by optimization techniques only when the underlying approach and performance criteria match their specific goals. In this contribution, we demonstrate the application of numerical optimization on a real-life problem. The Belgian utility De Watergroep is looking to not only reinforce its distribution networks but to also structurally modify the network’s topology to enhance the quality of water delivered in the future. To help the utility explore the possibilities of these far-reaching changes in the most flexible way possible, an optimization problem was formulated to optimize topology and pipe sizing simultaneously for the distribution network of a Belgian city. The objective of the problem is to minimize the volume of the looped network and thereby work towards a situation where most of the customers are fed by branched extremities of the network. This objective is constrained by pressure and fire flow requirements and thresholds on the number of customers on the branched sections. The requirements for continuity of supply under failure scenarios are guaranteed by these constraints, as verified in the final solution. The results of the optimization process show that it is possible to design a network which is 18.5% cheaper than the currently existing network. Moreover, it turns out the—previously completely meshed—topology can be restructured so that 67% of the network length is turned into branched clusters, with a meshed superstructure of 33% of the length remaining.