peer reviewed ; Medication-related errors represent a public health burden but are mainly preventable. A strategy to reduce medication errors could be pharmacist-nurse collaboration in weekly pillbox preparation. Unfortunately, there is little inventory in the literature on the actual pharmacist-nurse collaboration in weekly pillbox preparation and its added value in the healthcare practice. Objective: To assess the weekly pillbox preparation practices among home care nurses and community pharmacists, their collaboration for this service, and its added value, ultimately aiming to promote patient safety. Methods: An extensive survey was launched in French-speaking Belgium in 2022. The study occurred across two populations: home care nurses and community pharmacists in French-speaking Belgium. A self-administered questionnaire was developed. Three main outcomes were reported: the pillbox preparation, the medication plan, and the opinion about the pharmacist-nurse collaboration. A descriptive statistical analysis was carried out. Results: A total of 260 home care nurses and 204 community pharmacists answered the questionnaire. Our survey showed that weekly pillbox preparation was mainly performed by home care nurses (100%) than by community pharmacists (49%) in the primary care of the Belgian health system. There was only sometimes (or even no) remuneration for this service. Most home care nurses (82.7%) and community pharmacists (57.6%) have already pointed out errors in the medication plan used for the weekly pillbox preparation. The pharmacist-nurse collaboration for the weekly pillbox preparation was rare in Belgium. However, the majority of community pharmacists and home care nurses (more than 90% of both groups) would like to collaborate for this act, with the principal motivation of improving patient safety. Conclusion: Our survey showed that pharmacist- nurse collaboration in the weekly pillbox preparation was perceived as helpful in primary care with the ultimate goal of patient safety. Further studies are ...