Sabancaya volcano is the youngest and second most active volcano in Peru. It is part of the Ampato-Sabancaya volcanic complex which sits to the south of the ancient Hualca Hualca volcano and several frequently active faults, thus resulting in complex volcano-tectonic interactions. After 15 years of repose, in 2013, a series of 4 earthquakes with magnitude >4.5 occurred within 24 h, marking the beginning of a new episode of unrest. Several additional swarms of earthquakes occurred in the following years until magmatic eruptive activity started on 6 November 2016. This activity is ongoing as of this writing, with an average of 50 explosions per day. In this study, we present results of multiparametric monitoring of Sabancaya's activity observed during 2013–2020. Seismic data are used to create a one-dimensional seismic velocity model, to catalog, locate, and characterize earthquakes, to detect repeating earthquake families, and to monitor seismic velocity variations by ambient noise cross-correlation. These analyses are complemented by visual and remote sensing observations and ground deformation measurements. All monitored parameters showed significant changes on 6 November 2016, the day of eruption onset, thus dividing the eruptive activity into pre-eruptive and eruptive stages. The unrest is characterized by high levels of seismic activity with hundreds of events detected per day. Volcano-tectonic (VT) earthquakes were dominant during the pre-eruptive period while long-period (LP) events and explosions have been most numerous since the eruption onset. Earthquake locations highlight long-lasting seismogenic zones along multiple previously active regional faults, as well as along newly identified faults. This VT seismicity is mainly distributed in a sector from the northwest to the east of the volcanic complex at distances of up to 30 km from the crater. We focus our analysis on two eruptive episodes: the eruption onset and subsequent crater migration from south to north, and the increase of lava dome ...