This research represents the first study on the effect of different solvent extractions on the total phenols, tannins, and flavonoids content of indigenous medicinal plant Blumea arnakidophora from Sabah. A total of three solvent types were used in this study: 80% methanol, hot water and distilled water. Determination of phytochemical contents mentioned above was determined using Folin-Ciocalteu Reagent (FRC) method and Aluminium Chloride Colorimetry (ACC) method. The highest total phenols content (71.7 ± 7.0 mg GAE/g) and flavonoids content (33.7 ± 0.6 mg CE/g) were obtained from the 80% methanol extract from the leaves, whereas the highest tannin content (4.9 ± 0.7 mg GAE/g) was obtained from hot water extract from the leaves. From the statistical analyses, the phenols content extracted from the leaves with distilled water showed significant difference (p < 0.05) with hot water and 80% methanol extracts. The tannin content and flavonoid content extracted from the stems and leaves did not show any significant difference (p > 0.05) among the extraction solvent used. This work provides a preliminary result on selecting an effective extraction solvent for phytochemicals investigation on B. arnakidophora.