Signal hyposesis. Illustration

The signal hypothesis for secretory proteins formulated by Günter Blobel and David Sabatini. Blobel and Sabatini hypothesized in 1971 that a nascent peptide, bearing a terminal ‘signal’, interacts with a binding factor attached to the endoplasmic reticulum (ER) membrane, allowing docking of the ribosome and its associated mRNA. Upon passage of the newly synthesized protein across the ER membrane, the ribosome is able to dissociate from the site of synthesis and re-enter the cytoplasmic pool, ready for another round of synthesis. From Blobel, G. and Sabatini, D. (1971) in Biomembranes, pp.193-1... Mehr ...

Dokumenttyp: Text
Erscheinungsdatum: 2018
Verlag/Hrsg.: Digital Commons @ RU
Schlagwörter: David Sabatini / Günter Blobel / signal hypothesis
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-29243471
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://digitalcommons.rockefeller.edu/blobel-molecular-biology/28

The signal hypothesis for secretory proteins formulated by Günter Blobel and David Sabatini. Blobel and Sabatini hypothesized in 1971 that a nascent peptide, bearing a terminal ‘signal’, interacts with a binding factor attached to the endoplasmic reticulum (ER) membrane, allowing docking of the ribosome and its associated mRNA. Upon passage of the newly synthesized protein across the ER membrane, the ribosome is able to dissociate from the site of synthesis and re-enter the cytoplasmic pool, ready for another round of synthesis. From Blobel, G. and Sabatini, D. (1971) in Biomembranes, pp.193-195, Plenum Press, New York ; https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1024/thumbnail.jpg