Telah dilakukan formulasi tablet lepas lambat Natrium Diklofenak menggunakan matriks pati pisang kepok dan natrium karboksil metil selulosa sebagai pembandingnya. Tujuan penelitian ini untuk mengetahui apakah sediaan lepas lambat yang dibuat dengan matriks pati pisang kepok memenuhi persyaratan tablet lepas lambat. Hasil uji disolusi menunjukan formula I (Pati Pisang Kepok) terdisolusi sebesar 110,24 %, formula II (Natrium Karboksil Metil Selulosa) sebesar 39,04 % dalam waktu 8 jam. Dari hasil uji disolusi menunjukan bahwa pati pisang kepok belum memenuhi persyaratan sebagai matriks karena belum dapat memperlambat laju disolusi. Kinetika pelepasan zat aktif dari matriks antara kedua formula mengikuti persamaan Higuchi. ; The formulation of slow release tablet of diclofenac sodium using a matrix of starch from saba banana and sodium carboxyl methyl cellulose as a comparison has been done. The purpose of this study was to determine whether the slow-release preparations produced with starch from saba banana met the requirements of slow-release tablet . The dissolution test results show the formula I (starch of saba banana) was dissolved 110.24 %, formula II ( sodium carboxyl methyl cellulose ) was disolved 39.04 % within 8 hours. The dissolution test results showed that starch of saba banana did not meet the requirements as a matrix because it could not not reduce the rate of dissolution . The kinetics of the release of active substances from the matrix between the two formulas followed Higuchi equation .