Rhinovirus-induced VP1-specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms.
Rhinoviruses (RVs) are a major cause of common colds and induce exacerbations of asthma and chronic inflammatory lung diseases.We expressed and purified recombinant RV coat proteins VP1-4, non-structural proteins as well as N-terminal fragments of VP1 from four RV strains (RV14, 16, 89, C) covering the three known RV groups (RV-A, RV-B and RV-C) and measured specific IgG-subclass-, IgA- and IgM-responses by ELISA in subjects with different severities of asthma or without asthma before and after experimental infection with RV16.Before infection subjects showed IgG1 > IgA > IgM > IgG3 c... Mehr ...
| Verfasser: | |
|---|---|
| Dokumenttyp: | Journal article |
| Erscheinungsdatum: | 2014 |
| Verlag/Hrsg.: |
Elsevier: Creative Commons
|
| Schlagwörter: | Antibody response / Asthma / COPD / Chronic obstructive pulmonary disease / ELISA / Enzyme-linked immunosorbent assay / HRP / Horseradish peroxidase / HSA / Human serum albumin / ICAM-1 / Intercellular adhesion molecule 1 / ICS / Inhaled corticosteroids / LDL-R / Low density lipoprotein receptor / MALDI–TOF / Matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry / MBP / Maltose binding protein / O.D / Optical density / PEF / Peak expiratory flow / RV / Rhinovirus / Recombinant rhinovirus coat protein / SABA / Short-acting β2 agonists / Serological test / TCID50 / Tissue culture 50% infective dose |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29237913 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://hdl.handle.net/10044/1/26523 |
