Factors related to survival in hepatocellular carcinoma in the geographic area of Sabadell (Catalonia, Spain) Factores relacionados con la supervivencia en el carcinoma hepatocelular en el área geográfica de Sabadell

Background: hepatocellular carcinoma (HCC) is a very frequent tumor. Screening for the disease is effective, but the prognostic factors are difficult to evaluate. Objectives: 1. To determine epidemiological data and the clinical course of HCC in our setting. 2. To compare patient survival according to whether screening is performed or not. 3. To evaluate survival prognostic factors. Patients and methods: data on the epidemiology and clinical course of patients diagnosed with HCC were collected on a prospective basis (January 2004-December 2006). Two groups were considered according to whether... Mehr ...

Verfasser: Mireia Miquel
Julia Sopeña
Mercedes Vergara
Montserrat Gil
Meritxell Casas
Jorge Sánchez-Delgado
Jordi Puig
Anna Alguersuari
Eva Criado
Blai Dalmau
Dokumenttyp: Artikel
Erscheinungsdatum: 2012
Reihe/Periodikum: Revista Espanola de Enfermedades Digestivas, Vol 104, Iss 5, Pp 242-247 (2012)
Verlag/Hrsg.: Aran Ediciones
Schlagwörter: Carcinoma hepatocelular / Cirrosis / Cribado / Factores predictivos de supervivencia / Hepatocellular carcinoma / Cirrhosis / Screening / Survival predictive factors / Diseases of the digestive system. Gastroenterology / RC799-869
Sprache: Englisch
Spanish
Permalink: https://search.fid-benelux.de/Record/base-29235071
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doaj.org/article/a3023994448042588a22143da1bb8144

Background: hepatocellular carcinoma (HCC) is a very frequent tumor. Screening for the disease is effective, but the prognostic factors are difficult to evaluate. Objectives: 1. To determine epidemiological data and the clinical course of HCC in our setting. 2. To compare patient survival according to whether screening is performed or not. 3. To evaluate survival prognostic factors. Patients and methods: data on the epidemiology and clinical course of patients diagnosed with HCC were collected on a prospective basis (January 2004-December 2006). Two groups were considered according to whether screening had been performed (group A) or not (group B). Results: a total of 110 patients were diagnosed with HCC (70% males). The most common etiology of cirrhosis was hepatitis C (56.1%), and 69% presented mild liver failure (Child-Pugh grade A). The median follow-up was 1.8 years. Fifty-one percent had been subjected to screening. The diagnosis of HCC was established by imaging techniques in 48.2% of the cases, and by histological criteria in 51.8%. The median tumor size was 23 mm in group A and 28 mm in group B (p = 0.005). Treatment with curative intent was provided in 72% of the cases in group A and in 48% in group B (p = 0.011). The median overall survival was 1.99 years-2.67 years in group A and 1.75 years in group B (p = 0.05). The multivariate analysis of overall survival showed the type of treatment (OR = 2.82 95%CI: 1.3-6.12, p = 0.009) and liver function (OR = 1.71 95%CI: 1.1-2.68, p = 0.020) to be independent predictors of survival. Conclusions: screening allows the diagnosis of smaller lesions and a higher percentage of curative treatments. The degree of liver function and the provision of curative treatment are independent predictors of survival. Introducción: el carcinoma hepatocelular (CHC) es un tumor muy prevalente. Su cribado es eficaz, pero los factores pronósticos son difíciles de evaluar. Objetivos: 1. Conocer datos epidemiológicos y evolución clínica en nuestra área. 2. Comparar la supervivencia de ...