High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo ... : ارتفاع معدل انتشار الطفرة في جينات Plasmodium falciparum dhfr و dhps في الحقل المعزولة عن صباح، شمال بورنيو ...

Sulphadoxine-pyrimethamine (SP) has been in use for the treatment of uncomplicated falciparum malaria in Malaysia since the 1970s and is still widely employed in spite of widespread clinical resistance. Resistance to SP is known to be mediated by mutations in the pfdhfr and pfdhps genes. The aim of the present study was to investigate the distribution of pfdhfr and pfdhps gene polymorphism in Plasmodium falciparum field isolates from Kalabakan, Sabah, in northern Borneo. A total number of 619 individuals were screened from 23 study sites of which 31 were positive for P. falciparum. Analysis of... Mehr ...