The effect of heterogeneity in measles vaccination on population immunity
High overall vaccination levels sometimes hide pockets of poor coverage. We adopted a meta-population framework to model local aggregation of populations, and used this to investigate the effects of vaccination heterogeneity. A recent survey of antibody levels in a community with low vaccination levels in The Netherlands enabled us to assess the relative importance of local and long-range infective contacts, and thus identify feasible levels of aggregation in the meta-population model. In the aggregated model, we found that heterogeneity in vaccination coverage can lead to a much increased rat... Mehr ...
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| Dokumenttyp: | Journal article |
| Verlag/Hrsg.: |
Cambridge University Press
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| Schlagwörter: | Keywords: measles antibody / measles vaccine / age / article / community care / controlled study / feasibility study / health survey / immunity / infection rate / measles / measles vaccination / metapopulation / Netherlands / population model / population research / biological mod |
| Sprache: | unknown |
| Permalink: | https://search.fid-benelux.de/Record/base-29222509 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://hdl.handle.net/1885/79668 |
High overall vaccination levels sometimes hide pockets of poor coverage. We adopted a meta-population framework to model local aggregation of populations, and used this to investigate the effects of vaccination heterogeneity. A recent survey of antibody levels in a community with low vaccination levels in The Netherlands enabled us to assess the relative importance of local and long-range infective contacts, and thus identify feasible levels of aggregation in the meta-population model. In the aggregated model, we found that heterogeneity in vaccination coverage can lead to a much increased rate of infection among unvaccinated individuals, with a simultaneous drop in the average age at infection.