The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years

Abstract The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications... Mehr ...

Verfasser: McDonald, Scott A.
Lagerweij, Giske R.
de Boer, Pieter
de Melker, Hester E.
Pijnacker, Roan
Mughini Gras, Lapo
Kretzschmar, Mirjam E.
den Hartog, Gerco
van Gageldonk-Lafeber, Arianne B.
Hofhuis, Agnetha
Teirlinck, Anne
van Lier, Alies
Boudewijns, Bronke
de Dreu, Miek
Valk, Anne-Wil
Jongenotter, Femke
Verstraten, Carolien
Broekhaar, Gert
Willekens, Guido
Veldhuijzen, Irene
Polman, Jan
van de Kassteele, Jan
Alblas, Jeroen
van Heereveld, Janneke
Heijne, Janneke
Bulsink, Kirsten
Wielders, Lieke
van Asten, Liselotte
Jenniskens, Liz
Soetens, Loes
Mulder, Maarten
Schipper, Maarten
de Lange, Marit
Smorenburg, Naomi
Neppelenbroek, Nienke
van den Berg, Patrick
de Oliveira Bressane Lima, Priscila
van Gaalen, Rolina
Wijburg, Sara
de Bruijn, Shahabeh Abbas Zadeh Siméon
van Iersel, Senna
Andeweg, Stijn
Wierenga, Sjoerd
Lanooij, Susan
Keijser, Sylvia
Smit, Tara
Klinkenberg, Don
Backer, Jantien
McDonald, Scott
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: European Journal of Epidemiology ; volume 37, issue 10, page 1035-1047 ; ISSN 0393-2990 1573-7284
Verlag/Hrsg.: Springer Science and Business Media LLC
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29219689
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://dx.doi.org/10.1007/s10654-022-00895-0

Abstract The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700–290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620–1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions.