A highly virulent variant of HIV-1 circulating in the Netherlands

Verfasser:	Wymant, Chris Bezemer, Daniela Blanquart, François Ferretti, Luca Gall, Astrid Hall, Matthew Golubchik, Tanya Bakker, Margreet Ong, Swee Hoe Zhao, Lele Bonsall, David de Cesare, Mariateresa MacIntyre-Cockett, George Abeler-Dörner, Lucie Albert, Jan Bannert, Norbert Fellay, Jacques Grabowski, M Kate Gunsenheimer-Bartmeyer, Barbara Günthard, Huldrych F Kivelä, Pia Kouyos, Roger D Laeyendecker, Oliver Meyer, Laurence Porter, Kholoud Ristola, Matti van Sighem, Ard Berkhout, Ben Kellam, Paul Cornelissen, Marion Reiss, Peter Fraser, Christophe Aubert, V Battegay, M Bernasconi, E Böni, J Braun, D L Bucher, H C Burton-Jeangros, C Calmy, A Cavassini, M Dollenmaier, G Egger, M Elzi, L Fehr, J Fellay, J Furrer, H Fux, C A Gorgievski, M Günthard, H Haerry, D Hasse, B Hirsch, H H Hoffmann, M Hösli, I Kahlert, C Kaiser, L Keiser, O Klimkait, T Kouyos, R Kovari, H Ledergerber, B Martinetti, G de Tejada, B Martinez Marzolini, C Metzner, K Müller, N Nadal, D Nicca, D Pantaleo, G Rauch, A Regenass, S Rudin, C Schöni-Affolter, F Schmid, P Speck, R Stöckle, M Tarr, P Trkola, A Vernazza, P Weber, R Yerly, S van der Valk, M Geerlings, S E Goorhuis, A Hovius, J W Lempkes, B Nellen, F J B van der Poll, T Prins, J M Reiss, P van Vugt, M Wiersinga, W J Wit, F W M N van Duinen, M van Eden, J Hazenberg, A van Hes, A M H Pijnappel, F J J Smalhout, S Y Weijsenfeld, A M Jurriaans, S Back, N K T Zaaijer, H L Berkhout, B Cornelissen, M T E Schinkel, C J Wolthers, K C Peters, E J G van Agtmael, M A Autar, R S Bomers, M Sigaloff, K C E Heitmuller, M Laan, L M Ang, C W van Houdt, R Jonges, M Kuijpers, T W Pajkrt, D Scherpbier, H J de Boer, C van der Plas, A van den Berge, M Stegeman, A Baas, S Hage de Looff, L Buiting, A Reuwer, A Veenemans, J Wintermans, B Pronk, M J H Ammerlaan, H S M van den Bersselaar, D N J de Munnik, E S Deiman, B Jansz, A R Scharnhorst, V Tjhie, J Wegdam, M C A van Eeden, A Nellen, J Brokking, W Elsenburg, L J M Nobel, H van Kasteren, M E E Berrevoets, M A H Brouwer, A E Adams, A van Erve, R de Kruijf-van de Wiel, B A F M Keelan-Phaf, S van der Ven, B Buiting, A G M Murck, J L de Vries-Sluijs, T E M S Bax, H I van Gorp, E C M de Jong-Peltenburg, N C de Mendonç A Melo, M van Nood, E Nouwen, J L Rijnders, B J A Rokx, C Schurink, C A M Slobbe, L Verbon, A Bassant, N van Beek, J E A Vriesde, M van Zonneveld, L M de Groot, J Boucher, C A B Koopmans, M P G van Kampen, J J A Fraaij, P L A van Rossum, A M C Vermont, C L van der Knaap, L C Visser, E Branger, J Douma, R A Cents-Bosma, A S Duijf-van de Ven, C J H M Schippers, E F van Nieuwkoop, C van Ijperen, J M Geilings, J van der Hut, G van Burgel, N D Leyten, E M S Gelinck, L B S Mollema, F Davids-Veldhuis, S Tearno, C Wildenbeest, G S Heikens, E Groeneveld, P H P Bouwhuis, J W Lammers, A J J Kraan, S van Hulzen, A G W Kruiper, M S M van der Bliek, G L Bor, P C J Debast, S B Wagenvoort, G H J Kroon, F P de Boer, M G J Jolink, H Lambregts, M M C Roukens, A H E Scheper, H Dorama, W van Holten, N Claas, E C J Wessels, E den Hollander, J G El Moussaoui, R Pogany, K Smit, J V Struik-Kalkman, D van Niekerk, T Pontesilli, O Lowe, S H Oude Lashof, A M L Posthouwer, D van Wolfswinkel, M E Ackens, R P Burgers, K Schippers, J Weijenberg-Maes, B van Loo, I H M Havenith, T R A van Vonderen, M G A Kampschreur, L M Faber, S Steeman-Bouma, R Al Moujahid, A Kootstra, G J Delsing, C E van der Burg-van de Plas, M Scheiberlich, L Kortmann, W van Twillert, G Renckens, R Ruiter-Pronk, D van Truijen-Oud, F A Cohen Stuart, J W T Jansen, E R Hoogewerf, M Rozemeijer, W van der Reijden, W A Sinnige, J C Brinkman, K van den Berk, G E L Blok, W L Lettinga, K D de Regt, M Schouten, W E M Stalenhoef, J E Veenstra, J Vrouenraets, S M E Blaauw, H Geerders, G F Kleene, M J Kok, M Knapen, M van der Meché, I B Mulder-Seeleman, E Toonen, A J M Wijnands, S Wttewaal, E Kwa, D van Crevel, R van Aerde, K Dofferhoff, A S M Henriet, S S V Ter Hofstede, H J M Hoogerwerf, J Keuter, M Richel, O Albers, M Grintjes-Huisman, K J T de Haan, M Marneef, M Strik-Albers, R Rahamat-Langendoen, J Stelma, F F Burger, D Gisolf, E H Hassing, R J Claassen, M Ter Beest, G van Bentum, P H M Langebeek, N Tiemessen, R Swanink, C M A van Lelyveld, S F L Soetekouw, R van der Prijt, L M M van der Swaluw, J Bermon, N Jansen, R Herpers, B L Veenendaal, D Verhagen, D W M Lauw, F N van Broekhuizen, M C van Wijk, M Bierman, W F W Bakker, M Kleinnijenhuis, J Kloeze, E Middel, A Postma, D F Schölvinck, E H Stienstra, Y Verhage, A R Wouthuyzen-Bakker, M Boonstra, A de Groot-de Jonge, H van der Meulen, P A de Weerd, D A Niesters, H G M van Leer-Buter, C C Knoester, M Hoepelman, A I M Arends, J E Barth, R E Bruns, A H W Ellerbroek, P M Mudrikova, T Oosterheert, J J Schadd, E M van Welzen, B J Aarsman, K Griffioen-van Santen, B M G de Kroon, I van Berkel, M van Rooijen, C S A M Schuurman, R Verduyn-Lunel, F Wensing, A M J Bont, L J Geelen, S P M Loeffen, Y G T Wolfs, T F W Nauta, N Rooijakkers, E O W Holtsema, H Voigt, R van de Wetering, D Alberto, A van der Meer, I Rosingh, A Halaby, T Zaheri, S Boyd, A C Bezemer, D O van Sighem, A I Smit, C Hillebregt, M de Jong, A Woudstra, T Bergsma, D Meijering, R van de Sande, L Rutkens, T van der Vliet, S de Groot, L van den Akker, M Bakker, Y El Berkaoui, A Bezemer, M Brétin, N Djoechro, E Groters, M Kruijne, E Lelivelt, K J Lodewijk, C Lucas, E Munjishvili, L Paling, F Peeck, B Ree, C Regtop, R Ruijs, Y Schoorl, M Schnörr, P Scheigrond, A Tuijn, E Veenenberg, L Visser, K M Witte, E C Van Frankenhuijsen, Maartje Allegre, Thierry Makhloufi, Djamila Livrozet, Jean-Michel Chiarello, Pierre Godinot, Mathieu Brunel-Dalmas, Florence Gibert, Sylvie Trepo, Christian Peyramond, Dominique Miailhes, Patrick Koffi, Joseph Thoirain, Valérie Brochier, Corinne Baudry, Thomas Pailhes, Sylvie Lafeuillade, Alain Philip, Gisèle Hittinger, Gilles Assi, Assi Lambry, Véronique Rosenthal, Eric Naqvi, Alissa Dunais, Brigitte Cua, Eric Pradier, Christian Durant, Jacques Joulie, Aline Quinsat, Denis Tempesta, Serge Ravaux, Isabelle Martin, Isabelle Poizot Faucher, Olivia Cloarec, Nicolas Champagne, Hélène Pichancourt, Gilles Morlat, Philippe Pistone, Thierry Bonnet, Fabrice Mercie, Patrick Faure, Isabelle Hessamfar, Mojgan Malvy, Denis Lacoste, Denis Pertusa, Marie-Carmen Vandenhende, Marie-Anne Bernard, Noëlle Paccalin, François Martell, Cédric Roger-Schmelz, Julien Receveur, Marie-Catherine Duffau, Pierre Dondia, Denis Ribeiro, Emmanuel Caltado, Sabrina Neau, Didier Dupont, Michel Dutronc, Hervé Dauchy, Frédéric Cazanave, Charles Vareil, Marc-Olivier Wirth, Gaétane Le Puil, Séverine Pellegrin, Jean-Luc Raymond, Isabelle Viallard, Jean-François Chaigne de Lalande, Severin Garipuy, Daniel Delobel, Pierre Obadia, Martine Cuzin, Lise Alvarez, Muriel Biezunski, Noemie Porte, Lydie Massip, Patrice Debard, Alexa Balsarin, Florence Lagarrigue, Myriam Prevoteau du Clary, François Aquilina, Christian Reynes, Jacques Baillat, Vincent Merle, Corinne Lemoing, Vincent Atoui, Nadine Makinson, Alain Jacquet, Jean Marc Psomas, Christina Tramoni, Christine Aumaitre, Hugues Saada, Mathieu Medus, Marie Malet, Martine Eden, Aurélia Neuville, Ségolène Ferreyra, Milagros Sotto, Albert Barbuat, Claudine Rouanet, Isabelle Leureillard, Didier Mauboussin, Jean-Marc Lechiche, Catherine Donsesco, Régine Cabie, André Abel, Sylvie Pierre-Francois, Sandrine Batala, Anne-Sophie Cerland, Christophe Rangom, Camille Theresine, Nadine Hoen, Bruno Lamaury, Isabelle Fabre, Isabelle Schepers, Kinda Curlier, Elodie Ouissa, Rachida Gaud, Catherine Ricaud, Carole Rodet, Roland Wartel, Guillaume Sautron, Carmele Beck-Wirth, Geneviève Michel, Catherine Beck, Charles Halna, Jean-Michel Kowalczyk, Jakub Benomar, Meryem Drobacheff-Thiebaut, Christine Chirouze, Catherine Faucher, Jean-François Parcelier, François Foltzer, Adeline Haffner-Mauvais, Cécile Hustache Mathieu, Mathieu Proust, Aurélie Piroth, Lionel Chavanet, Pascal Duong, Michel Buisson, Marielle Waldner, Anne Mahy, Sophie Gohier, Sandrine Croisier, Delphine May, Thierry Delestan, Mikael Andre, Marie Zadeh, Mahsa Mohseni Martinot, Martin Rosolen, Béatrice Pachart, Anne Martha, Benoît Jeunet, Noëlle Rey, David Cheneau, Christine Partisani, Maria Priester, Michèle Bernard-Henry, Claudine Batard, Marie-Laure Fischer, Patricia Berger, Jean-Luc Kmiec, Isabelle Robineau, Olivier Huleux, Thomas Ajana, Faïza Alcaraz, Isabelle Allienne, Christophe Baclet, Véronique Meybeck, Agnès Valette, Michel Viget, Nathalie Aissi, Emmanuelle Biekre, Raphael Cornavin, Pauline Merrien, Dominique Seghezzi, Jean-Christophe Machado, Moise Diab, Georges Raffi, François Bonnet, Bénédicte Allavena, Clotilde Grossi, Olivier Reliquet, Véronique Billaud, Eric Brunet, Cecile Bouchez, Sabelline Morineau-Le Houssine, Pascale Sauser, Fabienne Boutoille, David Besnier, Michel Hue, Hervé Hall, Nolwenn Brosseau, Delphine Souala, Faouzi Michelet, Christian Tattevin, Pierre Arvieux, Cédric Revest, Matthieu Leroy, Helene Chapplain, Jean-Marc Dupont, Matthieu Fily, Fabien Patra-Delo, Solène Lefeuvre, Céline Bernard, Louis Bastides, Frédéric Nau, Pascale Verdon, Renaud de la Blanchardiere, Arnaud Martin, Anne Feret, Philippe Geffray, Loïk Daniel, Corinne Rohan, Jennifer Fialaire, Pascale Chennebault, Jean Marie Rabier, Valérie Abgueguen, Pierre Rehaiem, Sami Luycx, Odile Niault, Mathilde Moreau, Philippe Poinsignon, Yves Goussef, Marie Mouton-Rioux, Virginie Houlbert, Dominique Alvarez-Huve, Sandrine Barbe, Frédérique Haret, Sophie Perre, Philippe Leantez-Nainville, Sophie Esnault, Jean-Luc Guimard, Thomas Suaud, Isabelle Girard, Jean-Jacques Simonet, Véronique Debab, Yasmine Schmit, Jean-Luc Jacomet, Christine Weinberck, Pierre Genet, Claire Pinet, Pauline Ducroix, Sophie Durox, Hélène Denes, Éric Abraham, Bruno Gourdon, Florence Antoniotti, Odile Molina, Jean-Michel Ferret, Samuel Lascoux-Combe, Caroline Lafaurie, Matthieu Colin de Verdiere, Nathalie Ponscarme, Diane De Castro, Nathalie Aslan, Alexandre Rozenbaum, Willy Pintado, Claire Clavel, François Taulera, Olivier Gatey, Caroline Munier, Anne-Lise Gazaigne, Sandrine Penot, Pauline Conort, Guillaume Lerolle, Nathalie Leplatois, Anne Balausine, Stéphanie Delgado, Jeannine Timsit, Julie Tabet, Magda Gerard, Laurence Girard, Pierre-Marie Picard, Odile Tredup, Jürgen Bollens, Diane Valin, Nadia Campa, Pauline Bottero, Julie Lefebvre, Benedicte Tourneur, Muriel Fonquernie, Laurent Wemmert, Charlotte Lagneau, Jean-Luc Yazdanpanah, Yazdan Phung, Bao Pinto, Adriana Vallois, Dorothée Cabras, Ornella Louni, Françoise Pialoux, Gilles Lyavanc, Thomas Berrebi, Valérie Chas, Julie Lenagat, Sophie Rami, Agathe Diemer, Myriam Parrinello, Maguy Depond, Audrey Salmon, Dominique Guillevin, Loïc Tahi, Tassadit Belarbi, Linda Loulergue, Pierre Zak Dit Zbar, Olivier Launay, Odile Silbermann, Benjamin Leport, Catherine Alagna, Laura Pietri, Marie-Pierre Simon, Anne Bonmarchand, Manuela Amirat, Naouel Pichon, François Kirstetter, Myriam Katlama, Christine Valantin, Marc Antoine Tubiana, Roland Caby, Fabienne Schneider, Luminita Ktorza, Nadine Calin, Ruxandra Merlet, Audrey Ben Abdallah, Saadia Weiss, Laurence Buisson, Martin Batisse, Dominique Karmochine, Marina Pavie, Juliette Minozzi, Catherine Jayle, Didier Castel, Philippe Derouineau, Jean Kousignan, Pascale Eliazevitch, Murielle Pierre, Isabelle Collias, Lio Viard, Jean-Paul Gilquin, Jacques Sobel, Alain Slama, Laurence Ghosn, Jade Hadacek, Blanka Thu-Huyn, Nugyen Nait-Ighil, Lella Cros, Agnes Maignan, Aline Duvivier, Claudine Consigny, Paul Henri Lanternier, Fanny Shoai-Tehrani, Michka Touam, Fatima Jerbi, Saadia Bodard, Loïc Jung, Corinne Goujard, Cécile Quertainmont, Yann Duracinsky, Martin Segeral, Olivier Blanc, Arnaud Peretti, Delphine Cheret, Antoine Chantalat, Christelle Dulucq, Marie Josée Levy, Yves Lelievre, Jean Daniel Lascaux, Anne Sophie Dumont, Cécile Boue, François Chambrin, Véronique Abgrall, Sophie Kansau, Imad Raho-Moussa, Mariem De Truchis, Pierre Dinh, Aurélien Davido, Benjamin Marigot, Dhiba Berthe, Huguette Devidas, Alain Chevojon, Pierre Chabrol, Amélie Agher, Nouara Lemercier, Yvon Chaix, Fabrice Turpault, Isabelle Bouchaud, Olivier Honore, Patricia Rouveix, Elisabeth Reimann, Evelyne Belan, Alix Greder Godin Collet, Claire Souak, Safia Mortier, Emmanuel Bloch, Martine Simonpoli, Anne-Marie Manceron, Véronique Cahitte, Isabelle Hiraux, Emmanuel Lafon, Erik Cordonnier, François Zeng, Ai-Feng Zucman, David Majerholc, Catherine Bornarel, Dominique Uludag, Agnès Gellen-Dautremer, Justine Lefort, Agnès Bazin, Christine Daneluzzi, Vincent Gerbe, Juliette Jeantils, Vincent Coupard, Mélissa Patey, Olivier Bantsimba, Jonas Delllion, Sophie Paz, Pauline Caraux Cazenave, Benoit Richier, Laurent Garrait, Valérie Delacroix, Isabelle Elharrar, Brigitte Vittecoq, Daniel Bolliot, Claudine Lepretre, Annie Genet, Philippe Masse, Virginie Perrone, Véronique Boussard, Jean-Luc Chardon, Patricia Froguel, Eric Simon, Philippe Tassi, Sylvie Avettand Fenoel, Véronique Barin, Francis Bourgeois, Christine Cardon, Fanny Chaix, Marie-Laure Delfraissy, Jean François Essat, Asma Fischer, Hugues Lecuroux, Camille Petrov-Sanchez, Ventzislava Rouzioux, Christine Saez-Cirion, Asier Seng, Rémonie Kuldanek, Kristin Mullaney, Scott Young, Carmel Zucchetti, Antonella Bevan, Margaret-Ann McKernan, Sinead Wandolo, Emily Richardson, Celia Youssef, Elaney Green, Pippa Faulkner, Sue Faville, Rebecca Herman, Sandra Care, Christine Blackman, Helen Bellenger, Katharine Fairbrother, Keith Phillips, Andrew Babiker, Abdel Delpech, Valerie Fidler, S Clarke, Mindy Fox, Julie Gilson, R Goldberg, David Hawkins, David Johnson, Anne Johnson, Margaret McLean, Ken Nastouli, Eleni Post, Frank Kennedy, N Pritchard, J Andrady, U Rajda, N Donnelly, C McKernan, S Drake, S Gilleran, G White, D Ross, J Harding, J Faville, R Sweeney, J Flegg, P Toomer, S Wilding, H Woodward, R Dean, G Richardson, C Perry, N Gompels, M Jennings, L Bansaal, D Browing, M Connolly, L Stanley, B Estreich, S Magdy, A O'Mahony, C Fraser, P Jebakumar, S P R David, L Mette, R Summerfield, H Evans, M White, C Robertson, R Lean, C Morris, S Winter, A Faulkner, S Goorney, B Howard, L Fairley, I Stemp, C Short, L Gomez, M Young, F Roberts, M Green, S Sivakumar, K Minton, J Siminoni, A Calderwood, J Greenhough, D DeSouza, C Muthern, Lisa Orkin, C Murphy, S Truvedi, M McLean, K Hawkins, D Higgs, C Moyes, A Antonucci, S McCormack, S Lynn, W Bevan, M Fox, J Teague, A Anderson, J Mguni, S Post, F Campbell, L Mazhude, C Russell, H Carrick, G Ainsworth, J Waters, A Byrne, P Johnson, M Kuldanek, K Mullaney, S Lawlor, V Melville, R Sukthankar, A Thorpe, S Murphy, C Wilkins, E Ahmad, S Green, P Tayal, S Ong, E Meaden, J Riddell, L Loay, D Peacock, K Blackman, H Harindra, V Saeed, A M Allen, S Natarajan, U Williams, O Lacey, H Care, C Bowman, C Herman, S Devendra, S V Wither, J Bridgwood, A Singh, G Bushby, S Kellock, D Young, S Rooney, G Snart, B Currie, J Fitzgerald, M Arumainayyagam, J Chandramani, S Rajamanoharan, S Robinson, T Taylor, B Brewer, C Mayr, Christoph Schmidt, Wolfgang Speidel, Andrea Strohbach, Frank Arastéh, Keikawus Cordes, Christiane Stündel, Manfred Claus, Jörg Baumgarten, Axel Carganico, Andreas Ingiliz, Patrick Dupke, Stephan Freiwald, Matthias Rausch, Michael Moll, Arend Schleehauf, Dorothea Hintsche, Bettina Klausen, Gerd Jessen, Heiko Jessen, Arne Köppe, Siegfried Kreckel, Peter Schranz, Dietmar Fischer, Klaus Schulbin, Hubert Speer, Miriam Glaunsinger, Tobias Wicke, Thomas Bieniek, Bernhard Hillenbrand, Heribert Schlote, Frank Lauenroth-Mai, Elke Schuler, Christoph Schürmann, Dirk Wesselmann, Hans Brockmeyer, Norbert Gehring, Peter Schmalöer, Dirk Hower, Martin Spornraft-Ragaller, Petra Häussinger, Dieter Reuter, Stefan Esser, Stefan Markus, Rudolf Kreft, Burkhard Berzow, Dirk Christl, Andreas Meyer, Andreas Plettenberg, Andreas Stoehr, Albrecht Graefe, Katrin Lorenzen, Thore Adam, Axel Schewe, Knut Weitner, Lutwin Fenske, Stefan Hansen, Stefan Stellbrink, Hans-Jürgen Wiemer, Dorothea Hertling, Sandra Schmidt, Reinhold Arbter, Peter Claus, Bernd Galle, Peter Jäger, Hans Jä Gel-Guedes, Eva Postel, Nils Fröschl, Monika Spinner, Christoph Bogner, Johannes Salzberger, Bernd Schölmerich, Jürgen Audebert, Franz Marquardt, Ties Schaffert, Andreas Schnaitmann, Eiko Trein, Andreas Frietsch, Bernhard Müller, Marcus Ulmer, Albrecht Detering-Hübner, Barbara Kern, Peter Schubert, Franz Dehn, Günther Schreiber, Maria Güler, Cengiz Schmidt, Daniel Meixenberger, Karolin
Dokumenttyp:	Artikel
Erscheinungsdatum:	2022
Reihe/Periodikum:	Wymant , C , Bezemer , D , Blanquart , F , Ferretti , L , Gall , A , Hall , M , Golubchik , T , Bakker , M , Ong , S H , Zhao , L , Bonsall , D , de Cesare , M , MacIntyre-Cockett , G , Abeler-Dörner , L , Albert , J , Bannert , N , Fellay , J , Grabowski , M K , Gunsenheimer-Bartmeyer , B , Günthard , H F , Kivelä , P , Kouyos , R D , Laeyendecker , O , Meyer , L , Porter , K , Ristola , M , van Sighem , A , Berkhout , B , Kellam , P , Cornelissen , M , Reiss , P , Fraser , C , Aubert , V , Battegay , M , Bernasconi , E , Böni , J , Braun , D L , Bucher , H C , Burton-Jeangros , C , Calmy , A , Cavassini , M , Dollenmaier , G , Egger , M , Elzi , L , Fehr , J , Fellay , J , Furrer , H , Fux , C A , Gorgievski , M , Günthard , H , Haerry , D , Hasse , B , Hirsch , H H , Hoffmann , M , Hösli , I , Kahlert , C , Kaiser , L , Keiser , O , Klimkait , T , Kouyos , R , Kovari , H , Ledergerber , B , Martinetti , G , de Tejada , B M , Marzolini , C , Metzner , K , Müller , N , Nadal , D , Nicca , D , Pantaleo , G , Rauch , A , Regenass , S , Rudin , C , Schöni-Affolter , F , Schmid , P , Speck , R , Stöckle , M , Tarr , P , Trkola , A , Vernazza , P , Weber , R , Yerly , S , van der Valk , M , Geerlings , S E , Goorhuis , A , Hovius , J W , Lempkes , B , Nellen , F J B , van der Poll , T , Prins , J M , Reiss , P , van Vugt , M , Wiersinga , W J , Wit , F W M N , van Duinen , M , van Eden , J , Hazenberg , A , van Hes , A M H , Pijnappel , F J J , Smalhout , S Y , Weijsenfeld , A M , Jurriaans , S , Back , N K T , Zaaijer , H L , Berkhout , B , Cornelissen , M T E , Schinkel , C J , Wolthers , K C , Peters , E J G , van Agtmael , M A , Autar , R S , Bomers , M , Sigaloff , K C E , Heitmuller , M , Laan , L M , Ang , C W , van Houdt , R , Jonges , M , Kuijpers , T W , Pajkrt , D , Scherpbier , H J , de Boer , C , van der Plas , A , van den Berge , M , Stegeman , A , Baas , S , Hage de Looff , L , Buiting , A , Reuwer , A , Veenemans , J , Wintermans , B , Pronk , M J H , Ammerlaan , H S M , van den Bersselaar , D N J , de Munnik , E S , Deiman , B , Jansz , A R , Scharnhorst , V , Tjhie , J , Wegdam , M C A , van Eeden , A , Nellen , J , Brokking , W , Elsenburg , L J M , Nobel , H , van Kasteren , M E E , Berrevoets , M A H , Brouwer , A E , Adams , A , van Erve , R , de Kruijf-van de Wiel , B A F M , Keelan-Phaf , S , van der Ven , B , van der Ven , B , Buiting , A G M , Murck , J L , de Vries-Sluijs , T E M S , Bax , H I , van Gorp , E C M , de Jong-Peltenburg , N C , de Mendonç A Melo , M , van Nood , E , Nouwen , J L , Rijnders , B J A , Rokx , C , Schurink , C A M , Slobbe , L , Verbon , A , Bassant , N , van Beek , J E A , Vriesde , M , van Zonneveld , L M , de Groot , J , Boucher , C A B , Koopmans , M P G , van Kampen , J J A , Fraaij , P L A , van Rossum , A M C , Vermont , C L , van der Knaap , L C , Visser , E , Branger , J , Douma , R A , Cents-Bosma , A S , Duijf-van de Ven , C J H M , Schippers , E F , van Nieuwkoop , C , van Ijperen , J M , Geilings , J , van der Hut , G , van Burgel , N D , Leyten , E M S , Gelinck , L B S , Mollema , F , Davids-Veldhuis , S , Tearno , C , Wildenbeest , G S , Heikens , E , Groeneveld , P H P , Bouwhuis , J W , Lammers , A J J , Kraan , S , van Hulzen , A G W , Kruiper , M S M , van der Bliek , G L , Bor , P C J , Debast , S B , Wagenvoort , G H J , Kroon , F P , de Boer , M G J , Jolink , H , Lambregts , M M C , Roukens , A H E , Scheper , H , Dorama , W , van Holten , N , Claas , E C J , Wessels , E , den Hollander , J G , El Moussaoui , R , Pogany , K , Brouwer , A E , Smit , J V , Struik-Kalkman , D , van Niekerk , T , Pontesilli , O , Lowe , S H , Oude Lashof , A M L , Posthouwer , D , van Wolfswinkel , M E , Ackens , R P , Burgers , K , Schippers , J , Weijenberg-Maes , B , van Loo , I H M , Havenith , T R A , van Vonderen , M G A , Kampschreur , L M , Faber , S , Steeman-Bouma , R , Al Moujahid , A , Kootstra , G J , Delsing , C E , van der Burg-van de Plas , M 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Young , S , Rooney , G , Snart , B , Currie , J , Fitzgerald , M , Arumainayyagam , J , Chandramani , S , Rajamanoharan , S , Robinson , T , Taylor , B , Brewer , C , Mayr , C , Schmidt , W , Speidel , A , Strohbach , F , Arastéh , K , Cordes , C , Stündel , M , Claus , J , Baumgarten , A , Carganico , A , Ingiliz , P , Dupke , S , Freiwald , M , Rausch , M , Moll , A , Schleehauf , D , Hintsche , B , Klausen , G , Jessen , H , Jessen , A , Köppe , S , Kreckel , P , Schranz , D , Fischer , K , Schulbin , H , Speer , M , Glaunsinger , T , Wicke , T , Bieniek , B , Hillenbrand , H , Schlote , F , Lauenroth-Mai , E , Schuler , C , Schürmann , D , Wesselmann , H , Brockmeyer , N , Gehring , P , Schmalöer , D , Hower , M , Spornraft-Ragaller , P , Häussinger , D , Reuter , S , Esser , S , Markus , R , Kreft , B , Berzow , D , Christl , A , Meyer , A , Plettenberg , A , Stoehr , A , Graefe , K , Lorenzen , T , Adam , A , Schewe , K , Weitner , L , Fenske , S , Hansen , S , Stellbrink , H-J , Wiemer , D , Hertling , S , Schmidt , R , Arbter , P , Claus , B , Galle , P , Jäger , H , Jä Gel-Guedes , E , Postel , N , Fröschl , M , Spinner , C , Bogner , J , Salzberger , B , Schölmerich , J , Audebert , F , Marquardt , T , Schaffert , A , Schnaitmann , E , Trein , A , Frietsch , B , Müller , M , Ulmer , A , Detering-Hübner , B , Kern , P , Schubert , F , Dehn , G , Schreiber , M , Güler , C , Gunsenheimer-Bartmeyer , B , Schmidt , D , Meixenberger , K , Bannert , N & Netherlands ATHENA HIV Observational Cohort† 2022 , ' A highly virulent variant of HIV-1 circulating in the Netherlands ' , Science , vol. 375 , no. 6580 , A30 , pp. 540-545 . https://doi.org/10.1126/science.abk1688
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29216333
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vumc.nl/en/publications/b1227ff3-359f-455e-bf7b-ac8308fcf500

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.