Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of a... Mehr ...

Verfasser: Stringer, S
Minică, C.C.
Verweij, Karin J. H.
Mbarek, H
Bernard, M.
Derringer, J.
van Eijk, K.R.
Isen, J.D.
Loukola, A.
Maciejewski, D F
Mihailov, E.
van der Most, P.J.
Sánchez-Mora, C.
Roos, L.
Sherva, R.
Walters, R
Ware, J.J.
Abdellaoui, A
Bigdeli, T.B.
Branje, Susan J. T.
Brown, S.A.
Bruinenberg, M.
Casas, M.
Esko, T.
Garcia-Martinez, I.
Gordon, S.D.S.
Harris, J.M.
Hartman, Catharina A
Henders, A.K.
Heath, A.C.
Hickie, I.B.
Hickman, M.
Hopfer, C.J.
Hottenga, J. J.
Huizink, A C
Irons, D.E.
Kahn, R. S.
Korhonen, T.
Kranzler, H.R.
Krauter, K.
van Lier, P A C
Lubke, G H
Madden, P.A.F.
Mägi, R.
McGue, M K
Medland, Sarah E
Meeus, Wim H J
Miller, M.B.
Montgomery, Grant W
Nivard, M. G.
Nolte, Ilja M
Oldehinkel, Albertine J
Pausova, Z.
Qaiser, B.
Quaye, L.
Ramos-Quiroga, J.A.
Richarte, V.
Rose, Richard J.
Shin, J.
Stallings, M.C.
Stiby, A.I.
Wall, T L
Wright, M.J.
Koot, H M
Paus, T.
Hewitt, J.K.
Ribasés, M.
Kaprio, J
Boks, M.P.M.
Snieder, H.
Spector, T.
Munafò, M R
Metspalu, A.
Gelernter, J.
Boomsma, D. I.
Iacono, W.G.
Martin, Nicholas G
Gillespie, N.A.
Derks, E M
Vink, J M
Dokumenttyp: Artikel
Erscheinungsdatum: 2016
Reihe/Periodikum: Stringer , S , Minică , C C , Verweij , K J H , Mbarek , H , Bernard , M , Derringer , J , van Eijk , K R , Isen , J D , Loukola , A , Maciejewski , D F , Mihailov , E , van der Most , P J , Sánchez-Mora , C , Roos , L , Sherva , R , Walters , R , Ware , J J , Abdellaoui , A , Bigdeli , T B , Branje , S J T , Brown , S A , Bruinenberg , M , Casas , M , Esko , T , Garcia-Martinez , I , Gordon , S D S , Harris , J M , Hartman , C A , Henders , A K , Heath , A C , Hickie , I B , Hickman , M , Hopfer , C J , Hottenga , J J , Huizink , A C , Irons , D E , Kahn , R S , Korhonen , T , Kranzler , H R , Krauter , K , van Lier , P A C , Lubke , G H , Madden , P A F , Mägi , R , McGue , M K , Medland , S E , Meeus , W H J , Miller , M B , Montgomery , G W , Nivard , M G , Nolte , I M , Oldehinkel , A J , Pausova , Z , Qaiser , B , Quaye , L , Ramos-Quiroga , J A , Richarte , V , Rose , R J , Shin , J , Stallings , M C , Stiby , A I , Wall , T L , Wright , M J , Koot , H M , Paus , T , Hewitt , J K , Ribasés , M , Kaprio , J , Boks , M P M , Snieder , H , Spector , T , Munafò , M R , Metspalu , A , Gelernter , J , Boomsma , D I , Iacono , W G , Martin , N G , Gillespie , N A , Derks , E M & Vink , J M 2016 , ' Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium ' , Translational Psychiatry , vol. 6 , pp. e769 . https://doi.org/10.1038/tp.2016.36
Schlagwörter: Adolescent / Adult / Aged / 80 and over / Antigens / CD56 / Carrier Proteins / Cell Adhesion Molecules / Female / Genome-Wide Association Study / Humans / Male / Marijuana Abuse / Marijuana Smoking / Membrane Proteins / Middle Aged / Potassium Channels / Young Adult / Journal Article / Meta-Analysis / Research Support / N.I.H. / Extramural / U.S. Gov't / Non-P.H.S / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29215064
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/faa24f75-b8d4-446e-8905-e52474aca115