Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified a... Mehr ...
Verfasser: |
Demontis, Ditte
Walters, G. Bragi
Athanasiadis, Georgios
Boomsma, Dorret I.
Neale, Benjamin M.
Stefansson, Kari
Børglum, Anders D.
Dalsgaard, Søren
Martin, Joanna |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2023 |
Reihe/Periodikum: |
Demontis , D , Walters , G B , Athanasiadis , G , Boomsma , D I , Neale , B M , Stefansson , K , Børglum , A D , ADHD Working Group of the Psychiatric Genomics Consortium , iPSYCH-Broad Consortium , Dalsgaard , S & Martin , J 2023 , ' Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains ' , Nature genetics , vol. 55 , no. 2 , pp. 198-208 . https://doi.org/10.1038/s41588-022-01285-8 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-29214998 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/f09dfff0-36a1-4e06-981c-24e2b852f92e |