Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genomewide association study of first-phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 individuals without diabetes from 10 studies. We aimed to refine the mechanisms of 178 known associations between common variants and glycemic traits and identify new loci. Thirty type 2 diabetes or fasting glucose-raising alleles were associated with a m... Mehr ...
| Verfasser: |
Wood, Andrew R
Jonsson, Anna
Jackson, Anne U
Wang, Nan
van Leewen, Nienke
Palmer, Nicholette D
Kobes, Sayuko
Deelen, Joris
Boquete-Vilarino, Lorena
Paananen, Jussi
Stančáková, Alena
Boomsma, Dorret I
de Geus, J.C.N.
Eekhoff, Elisabeth Mw
Fritsche, Andreas
Kramer, Mark H H
Nijpels, Giel
Simonis-Bik, A.M.C.
van Haeften, Timon W
Mahajan, Anubha
Boehnke, Michael
Bergman, Richard N
Tuomilehto, Jaakko
Collins, Francis S
Mohlke, Karen L
Banasik, Karina
Groves, Christopher J
McCarthy, Mark I
Pearson, Ewan R
Natali, Andrea
Mari, Andrea
Buchanan, Thomas A
Taylor, Kent D
Xiang, Anny H
Gjesing, Anette P
Grarup, Niels
Eiberg, Hans
Pedersen, Oluf
Chen, Yii-Derr
Laakso, Markku
Norris, Jill M
Smith, Ulf
Wagenknecht, Lynne E
Baier, Leslie
Bowden, Donald W
Hansen, Torben
Walker, Mark
Watanabe, Richard M
't Hart, Leen M
Hanson, Robert L
Frayling, Timothy M |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Wood , A R , Jonsson , A , Jackson , A U , Wang , N , van Leewen , N , Palmer , N D , Kobes , S , Deelen , J , Boquete-Vilarino , L , Paananen , J , Stančáková , A , Boomsma , D I , de Geus , J C N , Eekhoff , E M , Fritsche , A , Kramer , M H H , Nijpels , G , Simonis-Bik , A M C , van Haeften , T W , Mahajan , A , Boehnke , M , Bergman , R N , Tuomilehto , J , Collins , F S , Mohlke , K L , Banasik , K , Groves , C J , McCarthy , M I , Pearson , E R , Natali , A , Mari , A , Buchanan , T A , Taylor , K D , Xiang , A H , Gjesing , A P , Grarup , N , Eiberg , H , Pedersen , O , Chen , Y-D , Laakso , M , Norris , J M , Smith , U , Wagenknecht , L E , Baier , L , Bowden , D W , Hansen , T , Walker , M , Watanabe , R M , 't Hart , L M , Hanson , R L & Frayling , T M 2017 , ' A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants ' , Diabetes , vol. 66 , no. 8 , pp. 2296-2309 . https://doi.org/10.2337/db16-1452 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214997 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/f0870ff2-3885-44e3-a1c4-d853c03c4962 |
