Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent di... Mehr ...
| Verfasser: |
Justice, Anne E
Winkler, Thomas W
Feitosa, Mary F
Graff, Misa
Fisher, Virginia A
Young, Kristin L
Barata, Llilda
Deng, Xuan
Czajkowski, Jacek
Hadley, David
Ngwa, Julius S
Ahluwalia, Tarunveer S
Chu, Audrey Y
Heard-Costa, Nancy L
Lim, Elise
Perez, Jeremiah
Eicher, John D
Kutalik, Zoltán
Xue, Luting
Mahajan, Anubha
Renström, Frida
Wu, Joseph
Qi, Qibin
Ahmad, Shafqat
Alfred, Tamuno
Amin, Najaf
Bielak, Lawrence F
Bonnefond, Amelie
Bragg-Gresham, Jennifer L
Cadby, Gemma
Chittani, Martina
Coggeshall, Scott
Corre, Tanguy
Direk, Nese
Eriksson, Joel
Fischer, Krista
Gorski, Mathias
Neergaard Harder, Marie
Horikoshi, Momoko
Huang, Tao
Huffman, Jennifer E
Jackson, Anne U
Justesen, Johanne Marie
Kanoni, Stavroula
Kinnunen, Leena
Kleber, Marcus E
Komulainen, Pirjo
Kumari, Meena
Lim, Unhee
Luan, Jian'an
Lyytikäinen, Leo-Pekka
Mangino, Massimo
Manichaikul, Ani
Marten, Jonathan
Middelberg, Rita P S
Müller-Nurasyid, Martina
Navarro, Pau
Pérusse, Louis
Pervjakova, Natalia
Sarti, Cinzia
Smith, Albert Vernon
Smith, Jennifer A
Stančáková, Alena
Strawbridge, Rona J
Stringham, Heather M
Sung, Yun Ju
Tanaka, Toshiko
Teumer, Alexander
Trompet, Stella
van der Laan, Sander W
van der Most, Peter J
van Vliet-Ostaptchouk, Jana V
Vedantam, Sailaja L
Verweij, Niek
Vink, Jacqueline M
Vitart, Veronique
Wu, Ying
Yengo, Loic
Zhang, Weihua
Hua Zhao, Jing
Zimmermann, Martina E
Zubair, Niha
Abecasis, Gonçalo R
Adair, Linda S
Afaq, Saima
Afzal, Uzma
Bakker, Stephan J L
Bartz, Traci M
Beilby, John
Bergman, Richard N
Bergmann, Sven
Biffar, Reiner
Blangero, John
Boerwinkle, Eric
Bonnycastle, Lori L
Bottinger, Erwin
Braga, Daniele
Buckley, Brendan M
Buyske, Steve
Campbell, Harry
Chambers, John C
Collins, Francis S
Curran, Joanne E
de Borst, Gert J
De Craen, Anton J M
de Geus, Eco J C
Dedoussis, George
Delgado, Graciela E
den Ruijter, Hester M
Eiriksdottir, Gudny
Eriksson, Anna L
Esko, Tõnu
Faul, Jessica D
Ford, Ian
Forrester, Terrence
Gertow, Karl
Gigante, Bruna
Glorioso, Nicola
Gong, Jian
Grallert, Harald
Grammer, Tanja B
Grarup, Niels
Haitjema, Saskia
Hallmans, Göran
Hamsten, Anders
Hansen, Torben
Harris, Tamara B
Hartman, Catharina A
Hassinen, Maija
Hastie, Nicholas D
Heath, Andrew C
Hernandez, Dena G
Hindorff, Lucia
Hocking, Lynne J
Hollensted, Mette
Holmen, Oddgeir L
Homuth, Georg
Huang, Jie
Hung, Joseph
Hutri-Kähönen, Nina
Ingelsson, Erik
James, Alan L
Jansson, John-Olov
Jarvelin, Marjo-Riitta
Jhun, Min A
Jørgensen, Marit E
Juonala, Markus
Kähönen, Mika
Karlsson, Magnus
Koistinen, Heikki A
Kolcic, Ivana
Kolovou, Genovefa
Kooperberg, Charles
Krämer, Bernhard K
Kuusisto, Johanna
Kvaløy, Kirsti
Lakka, Timo A
Langenberg, Claudia
Launer, Lenore J
Leander, Karin
Lee, Nanette R
Lind, Lars
Lindgren, Cecilia M
Linneberg, Allan
Lobbens, Stephane
Loh, Marie
Lorentzon, Mattias
Luben, Robert
Lubke, Gitta
Ludolph-Donislawski, Anja
Lupoli, Sara
Madden, Pamela A F
Männikkö, Reija
Marques-Vidal, Pedro M
Martin, Nicholas G
McKenzie, Colin A
McKnight, Barbara
Mellström, Dan
Menni, Cristina
Montgomery, Grant W
Musk, Aw Bill
Narisu, Narisu
Nauck, Matthias
Nolte, Ilja M
Oldehinkel, Albertine J
Olden, Matthias
Ong, Ken K
Padmanabhan, Sandosh
Peyser, Patricia A
Pisinger, Charlotta
Porteous, David J
Raitakari, Olli T
Rankinen, Tuomo
Rao, D.C.
Rasmussen-Torvik, Laura J
Rawal, Rajesh
Rice, Treva
Ridker, Paul M
Rose, Lynda M
Bien, Stephanie A
Rudan, Igor
Sanna, Serena
Sarzynski, Mark A
Sattar, Naveed
Savonen, Kai
Schlessinger, David
Scholtens, Salome
Schurmann, Claudia
Scott, Robert A
Sennblad, Bengt
Siemelink, Marten A
Silbernagel, Günther
Slagboom, P. Eline
Snieder, Harold
Staessen, Jan A
Stott, David J
Swertz, Morris a.
Swift, Amy J
Taylor, Kent D
Tayo, Bamidele O
Thorand, Barbara
Thuillier, Dorothee
Tuomilehto, Jaakko
Uitterlinden, Andre G
Vandenput, Liesbeth
Vohl, Marie-Claude
Völzke, Henry
Vonk, Judith M
Waeber, Gérard
Waldenberger, Melanie
Westendorp, R.G.J.
Wild, Sarah
Willemsen, Gonneke
Wolffenbuttel, Bruce H R
Wong, Andrew
Wright, Alan F
Zhao, Wei
Zillikens, M Carola
Baldassarre, Damiano
Balkau, Beverley
Bandinelli, Stefania
Böger, Carsten A
Boomsma, Dorret I
Bouchard, Claude
Bruinenberg, Marcel
Chasman, Daniel I
Chen, Yii-DerIda
Chines, Peter S
Cooper, Richard S
Cucca, Francesco
Cusi, Daniele
Faire, Ulf de
Ferrucci, Luigi
Franks, Paul W
Froguel, Philippe
Gordon-Larsen, Penny
Grabe, Hans-Jörgen
Gudnason, Vilmundur
Haiman, Christopher A
Hayward, Caroline
Hveem, Kristian
Johnson, Andrew D
Wouter Jukema, J
Kardia, Sharon L R
Kivimaki, Mika
Kooner, Jaspal S
Kuh, Diana
Laakso, Markku
Lehtimäki, Terho
Marchand, Loic Le
März, Winfried
McCarthy, Mark I
Metspalu, Andres
Morris, Andrew P
Ohlsson, Claes
Palmer, Lyle J
Pasterkamp, Gerard
Pedersen, Oluf
Peters, Annette
Peters, Ulrike
Polasek, Ozren
Psaty, Bruce M
Qi, Lu
Rauramaa, Rainer
Smith, Blair H
Sørensen, Thorkild I A
Strauch, Konstantin
Tiemeier, Henning
Tremoli, Elena
van der Harst, Pim
Vestergaard, Henrik
Vollenweider, Peter
Wareham, Nicholas J
Weir, David R
Whitfield, John B
Wilson, James F
Tyrrell, Jessica
Frayling, Timothy M
Barroso, Inês
Boehnke, Michael
Deloukas, Panagiotis
Fox, Caroline S
Hirschhorn, Joel N
Hunter, David J
Spector, Tim D
Strachan, David P
van Duijn, Cornelia M
Heid, Iris M
Mohlke, Karen L
Marchini, Jonathan
Loos, Ruth J F
Kilpeläinen, Tuomas O
Liu, Ching-Ti
Borecki, Ingrid B
North, Kari E
Cupples, L Adrienne
Hottenga, J.J. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Justice , A E , Winkler , T W , Feitosa , M F , Graff , M , Fisher , V A , Young , K L , Barata , L , Deng , X , Czajkowski , J , Hadley , D , Ngwa , J S , Ahluwalia , T S , Chu , A Y , Heard-Costa , N L , Lim , E , Perez , J , Eicher , J D , Kutalik , Z , Xue , L , Mahajan , A , Renström , F , Wu , J , Qi , Q , Ahmad , S , Alfred , T , Amin , N , Bielak , L F , Bonnefond , A , Bragg-Gresham , J L , Cadby , G , Chittani , M , Coggeshall , S , Corre , T , Direk , N , Eriksson , J , Fischer , K , Gorski , M , Neergaard Harder , M , Horikoshi , M , Huang , T , Huffman , J E , Jackson , A U , Justesen , J M , Kanoni , S , Kinnunen , L , Kleber , M E , Komulainen , P , Kumari , M , Lim , U , Luan , J , Lyytikäinen , L-P , Mangino , M , Manichaikul , A , Marten , J , Middelberg , R P S , Müller-Nurasyid , M , Navarro , P , Pérusse , L , Pervjakova , N , Sarti , C , Smith , A V , Smith , J A , Stančáková , A , Strawbridge , R J , Stringham , H M , Sung , Y J , Tanaka , T , Teumer , A , Trompet , S , van der Laan , S W , van der Most , P J , van Vliet-Ostaptchouk , J V , Vedantam , S L , Verweij , N , Vink , J M , Vitart , V , Wu , Y , Yengo , L , Zhang , W , Hua Zhao , J , Zimmermann , M E , Zubair , N , Abecasis , G R , Adair , L S , Afaq , S , Afzal , U , Bakker , S J L , Bartz , T M , Beilby , J , Bergman , R N , Bergmann , S , Biffar , R , Blangero , J , Boerwinkle , E , Bonnycastle , L L , Bottinger , E , Braga , D , Buckley , B M , Buyske , S , Campbell , H , Chambers , J C , Collins , F S , Curran , J E , de Borst , G J , De Craen , A J M , de Geus , E J C , Dedoussis , G , Delgado , G E , den Ruijter , H M , Eiriksdottir , G , Eriksson , A L , Esko , T , Faul , J D , Ford , I , Forrester , T , Gertow , K , Gigante , B , Glorioso , N , Gong , J , Grallert , H , Grammer , T B , Grarup , N , Haitjema , S , Hallmans , G , Hamsten , A , Hansen , T , Harris , T B , Hartman , C A , Hassinen , M , Hastie , N D , Heath , A C , Hernandez , D G , Hindorff , L , Hocking , L J , Hollensted , M , Holmen , O L , Homuth , G , Huang , J , Hung , J , Hutri-Kähönen , N , Ingelsson , E , James , A L , Jansson , J-O , Jarvelin , M-R , Jhun , M A , Jørgensen , M E , Juonala , M , Kähönen , M , Karlsson , M , Koistinen , H A , Kolcic , I , Kolovou , G , Kooperberg , C , Krämer , B K , Kuusisto , J , Kvaløy , K , Lakka , T A , Langenberg , C , Launer , L J , Leander , K , Lee , N R , Lind , L , Lindgren , C M , Linneberg , A , Lobbens , S , Loh , M , Lorentzon , M , Luben , R , Lubke , G , Ludolph-Donislawski , A , Lupoli , S , Madden , P A F , Männikkö , R , Marques-Vidal , P M , Martin , N G , McKenzie , C A , McKnight , B , Mellström , D , Menni , C , Montgomery , G W , Musk , A B , Narisu , N , Nauck , M , Nolte , I M , Oldehinkel , A J , Olden , M , Ong , K K , Padmanabhan , S , Peyser , P A , Pisinger , C , Porteous , D J , Raitakari , O T , Rankinen , T , Rao , D C , Rasmussen-Torvik , L J , Rawal , R , Rice , T , Ridker , P M , Rose , L M , Bien , S A , Rudan , I , Sanna , S , Sarzynski , M A , Sattar , N , Savonen , K , Schlessinger , D , Scholtens , S , Schurmann , C , Scott , R A , Sennblad , B , Siemelink , M A , Silbernagel , G , Slagboom , P E , Snieder , H , Staessen , J A , Stott , D J , Swertz , M A , Swift , A J , Taylor , K D , Tayo , B O , Thorand , B , Thuillier , D , Tuomilehto , J , Uitterlinden , A G , Vandenput , L , Vohl , M-C , Völzke , H , Vonk , J M , Waeber , G , Waldenberger , M , Westendorp , R G J , Wild , S , Willemsen , G , Wolffenbuttel , B H R , Wong , A , Wright , A F , Zhao , W , Zillikens , M C , Baldassarre , D , Balkau , B , Bandinelli , S , Böger , C A , Boomsma , D I , Bouchard , C , Bruinenberg , M , Chasman , D I , Chen , Y-D , Chines , P S , Cooper , R S , Cucca , F , Cusi , D , Faire , U D , Ferrucci , L , Franks , P W , Froguel , P , Gordon-Larsen , P , Grabe , H-J , Gudnason , V , Haiman , C A , Hayward , C , Hveem , K , Johnson , A D , Wouter Jukema , J , Kardia , S L R , Kivimaki , M , Kooner , J S , Kuh , D , Laakso , M , Lehtimäki , T , Marchand , L L , März , W , McCarthy , M I , Metspalu , A , Morris , A P , Ohlsson , C , Palmer , L J , Pasterkamp , G , Pedersen , O , Peters , A , Peters , U , Polasek , O , Psaty , B M , Qi , L , Rauramaa , R , Smith , B H , Sørensen , T I A , Strauch , K , Tiemeier , H , Tremoli , E , van der Harst , P , Vestergaard , H , Vollenweider , P , Wareham , N J , Weir , D R , Whitfield , J B , Wilson , J F , Tyrrell , J , Frayling , T M , Barroso , I , Boehnke , M , Deloukas , P , Fox , C S , Hirschhorn , J N , Hunter , D J , Spector , T D , Strachan , D P , van Duijn , C M , Heid , I M , Mohlke , K L , Marchini , J , Loos , R J F , Kilpeläinen , T O , Liu , C-T , Borecki , I B , North , K E , Cupples , L A & Hottenga , J J 2017 , ' Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits ' , Nature Communications , vol. 8 , 14977 , pp. 14977 . https://doi.org/10.1038/ncomms14977 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214892 |
| Datenquelle: |
BASE;
Originalkatalog |
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BASE |
| Link(s) :
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https://research.vu.nl/en/publications/e0fc5e12-575e-440d-95ef-db800338568e |
