Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analys... Mehr ...
| Verfasser: |
Liu, Jun
Carnero-Montoro, Elena
van Dongen, Jenny
Lent, Samantha
Nedeljkovic, Ivana
Ligthart, Symen
Tsai, Pei Chien
Martin, Tiphaine C.
Mandaviya, Pooja R.
Jansen, Rick
Peters, Marjolein J.
Duijts, Liesbeth
Jaddoe, Vincent W.V.
Tiemeier, Henning
Felix, Janine F.
Willemsen, Gonneke
de Geus, Eco J.C.
Chu, Audrey Y.
Levy, Daniel
Hwang, Shih Jen
Bressler, Jan
Gondalia, Rahul
Salfati, Elias L.
Herder, Christian
Hidalgo, Bertha A.
Tanaka, Toshiko
Moore, Ann Zenobia
Lemaitre, Rozenn N.
Jhun, Min A.
Smith, Jennifer A.
Sotoodehnia, Nona
Bandinelli, Stefania
Ferrucci, Luigi
Arnett, Donna K.
Grallert, Harald
Assimes, Themistocles L.
Hou, Lifang
Baccarelli, Andrea
Whitsel, Eric A.
van Dijk, Ko Willems
Amin, Najaf
Uitterlinden, André G.
Sijbrands, Eric J.G.
Franco, Oscar H.
Dehghan, Abbas
Spector, Tim D.
Dupuis, Josée
Hivert, Marie France
Rotter, Jerome I.
Meigs, James B.
Pankow, James S.
van Meurs, Joyce B.J.
Isaacs, Aaron
Boomsma, Dorret I.
Bell, Jordana T.
Demirkan, Ayşe
van Duijn, Cornelia M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Reihe/Periodikum: |
Liu , J , Carnero-Montoro , E , van Dongen , J , Lent , S , Nedeljkovic , I , Ligthart , S , Tsai , P C , Martin , T C , Mandaviya , P R , Jansen , R , Peters , M J , Duijts , L , Jaddoe , V W V , Tiemeier , H , Felix , J F , Willemsen , G , de Geus , E J C , Chu , A Y , Levy , D , Hwang , S J , Bressler , J , Gondalia , R , Salfati , E L , Herder , C , Hidalgo , B A , Tanaka , T , Moore , A Z , Lemaitre , R N , Jhun , M A , Smith , J A , Sotoodehnia , N , Bandinelli , S , Ferrucci , L , Arnett , D K , Grallert , H , Assimes , T L , Hou , L , Baccarelli , A , Whitsel , E A , van Dijk , K W , Amin , N , Uitterlinden , A G , Sijbrands , E J G , Franco , O H , Dehghan , A , Spector , T D , Dupuis , J , Hivert , M F , Rotter , J I , Meigs , J B , Pankow , J S , van Meurs , J B J , Isaacs , A , Boomsma , D I , Bell , J T , Demirkan , A & van Duijn , C M 2019 , ' An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis ' , Nature Communications , vol. 10 , 2581 , pp. 1-11 . https://doi.org/10.1038/s41467-019-10487-4 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214885 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/df85b113-78ad-4ce6-a5bd-bce3e13956ff |
