Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust... Mehr ...
Verfasser: |
Perry, J.R.B.
Day, F.R.
Elks, C.E.
Sulem, P.
Thompson, D.J.
Ferreira, T.
He, C.
Chasman, D.I.
Esko, T.
Thorleifsson, G.
Albrecht, E.
Ang, W.Q.
Corre, T.
Cousminer, D.L.
Feenstra, B.
Franceschini, N.
Ganna, A.
Johnson, A.D.
Kjellqvist, S.
Lunetta, K.L.
McMahon, G.
Nolte, I.M.
Paternoster, L.
Porcu, E.
Smith, A.V.
Stolk, L.
Teumer, A.
Tsernikova, N.
Tikkanen, E.
Ulivi, S.
Wagner, E.K.
Amin, N.
Bierut, L.J.
Byrne, E.M.
Hottenga, J.J.
Koller, D.L.
Mangino, M.
Pers, T.H.
Yerges-Armstrong, L.M.
Zhao, J.H.
Andrulis, I.L.
Anton-Culver, H.
Atsma, F.
Bandinelli, S.
Beckmann, M.W.
Benitez, J.
Blomqvist, C.
Bojesen, S.E.
Bolla, M.K.
Bonanni, B.
Brauch, H.
Brenner, H.
Buring, J.E.
Chang-Claude, J.
Chanock, S.
Chen, J.
Chenevix-Trench, G.
Collee, J.M.
Couch, F.J.
Couper, D.
Coviello, A.D.
Cox, A.
Czene, K.
Pio d'Adamo, A.
Smith, G.D.
De Vivo, I.
Demerath, E.W.
Dennis, J.
Devilee, P.
Dieffenbach, A.K.
Dunning, A.M.
Eiriksdottir, G.
Eriksson, J.G.
Fasching, P.A.
Ferrucci, L.
Flesch-Janys, D.
Flyger, H.
Foroud, T.
Franke, L.
Garcia, M.E.
Garcia-Closas, M.
Geller, F.
de Geus, E.J.C.
Giles, G.G.
Gudbjartsson, D.F.
Gudnason, V.
Guenel, P.
Guo, S.
Hall, P.
Hamann, U.
Haring, R.
Hartman, C.A.
Heath, A.C.
Hofman, A.
Hooning, M.J.
Hopper, J.L.
Hu, F.B.
Hunter, D.J.
Karasik, D.
Kiel, D.P.
Knight, J.A.
Kosma, V.M.
Kutalik, Z.
Lai, S.
Lambrechts, D.
Lindblom, A.
Mägi, R.
Magnusson, P.K.
Mannermaa, A.
Martin, N.G.
Masson, G.
McArdle, P.F.
McArdle, W.L.
Melbye, M.
Michailidou, K.
Mihailov, E.
Milani, L.
Milne, R.L.
Nevanlinna, H.
Neven, P.
Nohr, E.A.
Oldehinkel, A.J.
Oostra, B.A.
Palotie, A.
Peacock, M.
Pedersen, N.L.
Peterlongo, P.
Peto, J.
Pharoah, P.D.P.
Postma, D.S.
Pouta, A.
Pylkäs, K.
Radice, P.
Ring, S.
Rivadeneira, F.
Robino, A.
Rose, L.M.
Rudolph, A.
Salomaa, V.
Sanna, S.
Schlessinger, D.
Schmidt, M.K.
Southey, M.C.
Sovio, U.
Stampfer, M.J.
Stöckl, D.
Storniolo, A.M.
Timpson, N.J.
Tyrer, J.
Visser, J.A.
Vollenweider, P.
Völzke, H.
Waeber, G.
Waldenberger, M.
Wallaschofski, H.
Wang, Q.
Willemsen, G.
Winqvist, R.
Wolffenbuttel, B.H.R.
Wright, M.J.
Boomsma, D.I.
Econs, M.J.
Khaw, K.T.
Loos, R.J.F.
McCarthy, M.I.
Montgomery, G.W.
Rice, J.P.
Streeten, E.A.
Thorsteinsdottir, U.
van Duijn, C.M.
Alizadeh, BZ
Bergmann, S.
Boerwinkle, E.
Boyd, H.A.
Crisponi, L.
Gasparini, P.
Gieger, C.
Harris, T.B.
Ingelsson, E.
Järvelin, M.R.
Kraft, P.
Lawlor, D.
Metspalu, A.
Pennell, C.E.
Ridker, P.M.
Snieder, H.
Sorensen, T.I.A.
Spector, T.D.
Strachan, D.P.
Uitterlinden, A.G.
Wareham, N.J.
Widen, E.
Zygmunt, M.
Murray, A.
Easton, D.F.
Stefansson, K.
Murabito, J.M.
Ong, K.K. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2014 |
Reihe/Periodikum: |
Perry , J R B , Day , F R , Elks , C E , Sulem , P , Thompson , D J , Ferreira , T , He , C , Chasman , D I , Esko , T , Thorleifsson , G , Albrecht , E , Ang , W Q , Corre , T , Cousminer , D L , Feenstra , B , Franceschini , N , Ganna , A , Johnson , A D , Kjellqvist , S , Lunetta , K L , McMahon , G , Nolte , I M , Paternoster , L , Porcu , E , Smith , A V , Stolk , L , Teumer , A , Tsernikova , N , Tikkanen , E , Ulivi , S , Wagner , E K , Amin , N , Bierut , L J , Byrne , E M , Hottenga , J J , Koller , D L , Mangino , M , Pers , T H , Yerges-Armstrong , L M , Zhao , J H , Andrulis , I L , Anton-Culver , H , Atsma , F , Bandinelli , S , Beckmann , M W , Benitez , J , Blomqvist , C , Bojesen , S E , Bolla , M K , Bonanni , B , Brauch , H , Brenner , H , Buring , J E , Chang-Claude , J , Chanock , S , Chen , J , Chenevix-Trench , G , Collee , J M , Couch , F J , Couper , D , Coviello , A D , Cox , A , Czene , K , Pio d'Adamo , A , Smith , G D , De Vivo , I , Demerath , E W , Dennis , J , Devilee , P , Dieffenbach , A K , Dunning , A M , Eiriksdottir , G , Eriksson , J G , Fasching , P A , Ferrucci , L , Flesch-Janys , D , Flyger , H , Foroud , T , Franke , L , Garcia , M E , Garcia-Closas , M , Geller , F , de Geus , E J C , Giles , G G , Gudbjartsson , D F , Gudnason , V , Guenel , P , Guo , S , Hall , P , Hamann , U , Haring , R , Hartman , C A , Heath , A C , Hofman , A , Hooning , M J , Hopper , J L , Hu , F B , Hunter , D J , Karasik , D , Kiel , D P , Knight , J A , Kosma , V M , Kutalik , Z , Lai , S , Lambrechts , D , Lindblom , A , Mägi , R , Magnusson , P K , Mannermaa , A , Martin , N G , Masson , G , McArdle , P F , McArdle , W L , Melbye , M , Michailidou , K , Mihailov , E , Milani , L , Milne , R L , Nevanlinna , H , Neven , P , Nohr , E A , Oldehinkel , A J , Oostra , B A , Palotie , A , Peacock , M , Pedersen , N L , Peterlongo , P , Peto , J , Pharoah , P D P , Postma , D S , Pouta , A , Pylkäs , K , Radice , P , Ring , S , Rivadeneira , F , Robino , A , Rose , L M , Rudolph , A , Salomaa , V , Sanna , S , Schlessinger , D , Schmidt , M K , Southey , M C , Sovio , U , Stampfer , M J , Stöckl , D , Storniolo , A M , Timpson , N J , Tyrer , J , Visser , J A , Vollenweider , P , Völzke , H , Waeber , G , Waldenberger , M , Wallaschofski , H , Wang , Q , Willemsen , G , Winqvist , R , Wolffenbuttel , B H R , Wright , M J , Boomsma , D I , Econs , M J , Khaw , K T , Loos , R J F , McCarthy , M I , Montgomery , G W , Rice , J P , Streeten , E A , Thorsteinsdottir , U , van Duijn , C M , Alizadeh , BZ , Bergmann , S , Boerwinkle , E , Boyd , H A , Crisponi , L , Gasparini , P , Gieger , C , Harris , T B , Ingelsson , E , Järvelin , M R , Kraft , P , Lawlor , D , Metspalu , A , Pennell , C E , Ridker , P M , Snieder , H , Sorensen , T I A , Spector , T D , Strachan , D P , Uitterlinden , A G , Wareham , N J , Widen , E , Zygmunt , M , Murray , A , Easton , D F , Stefansson , K , Murabito , J M & Ong , K K 2014 , ' Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche ' , Nature , vol. 514 , no. 7520 , pp. 92-97 . https://doi.org/10.1038/nature13545 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-29214762 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
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https://research.vu.nl/en/publications/cb8b7c99-b1db-4447-9d07-92dff7b3ec00 |