Background: Genome-wide association studies in Japanese populations recently identified common variants in the KCNQ1 gene to be associated with type 2 diabetes. We examined the association of these variants within KCNQ1 with type 2 diabetes in a Dutch population, investigated their effects on insulin secretion and metabolic traits and on the risk of developing complications in type 2 diabetes patients. Methodology: The KCNQ1 variants rs151290, rs2237892, and rs2237895 were genotyped in a total of 4620 type 2 diabetes patients and 5285 healthy controls from the Netherlands. Data on macrovascula... Mehr ...
| Verfasser: |
van Vliet-Ostaptchouk, J.V.
van Haeften, T.W.
Landman, G.W.D.
Reiling, E.
Kleefstra, N.
Bilo, H.J.G.
Klungel, O.H.
de Boer, A.
van Diemen, C.C.
Wijmenga, C.
Boezen, H.M.
Dekker, J.M.
van 't Riet, E.
Nijpels, G.
Welschen, L.M.C.
Zavrelová, H.
Bruin, E.J.
Elbers, C.C.
Bauer, F.
Onland-Moret, N.C.
van der Schouw, Y.T.
Grobbee, D.E.
Spijkerman, A.M.W.
van der Aa, D.L.
Bik-Simonis, A.M.C.
Eekhoff, E.M.W.
Diamant, M.
Kramer, M.H.H.
Boomsma, D.I.
de Geus, E.J.C.
Willemsen, G.
Slagboom, P.E.
Hofker, M.H.
Hart, L.M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2012 |
| Reihe/Periodikum: |
van Vliet-Ostaptchouk , J V , van Haeften , T W , Landman , G W D , Reiling , E , Kleefstra , N , Bilo , H J G , Klungel , O H , de Boer , A , van Diemen , C C , Wijmenga , C , Boezen , H M , Dekker , J M , van 't Riet , E , Nijpels , G , Welschen , L M C , Zavrelová , H , Bruin , E J , Elbers , C C , Bauer , F , Onland-Moret , N C , van der Schouw , Y T , Grobbee , D E , Spijkerman , A M W , van der Aa , D L , Bik-Simonis , A M C , Eekhoff , E M W , Diamant , M , Kramer , M H H , Boomsma , D I , de Geus , E J C , Willemsen , G , Slagboom , P E , Hofker , M H & Hart , L M 2012 , ' Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp ' , PLoS ONE , vol. 7 , no. 3 , e32148 . https://doi.org/10.1371/journal.pone.0032148 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214680 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/c1fecb2c-5fc7-4320-9d3a-46f31e1c630e |
